GABA-Induced Intracellular Mg2+ Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks

Ryu Yamanaka, Yutaka Shindo, Kohji Hotta, Koji Suzuki, Kotaro Oka

Research output: Contribution to journalArticle

7 Citations (Scopus)


Yamanaka et al. demonstrate that GABA triggers mitochondrial Mg2+ release in neurons at specifically developmental early stages, and the physiological Mg2+ redistribution into cytoplasm regulates ERK, CREB, and mTOR activities with target-dependent manners, thereby facilitating neuronal maturation. Mg2+ is a novel signal transducer.

Original languageEnglish
Pages (from-to)3984-3991.e5
JournalCurrent Biology
Issue number24
Publication statusPublished - 2018 Dec 17



  • cellular information processing
  • GABA
  • magnesium ion
  • neuronal development
  • signal transduction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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