Abstract
A neocortex is present in all mammals but is not present in other classes of vertebrates, and the neocortex is extremely elaborate in humans. Changes in excitatory projection neurons and their progenitors within the developing dorsal pallium in the most recent common ancestor of mammals are thought to have been involved in the evolution of the neocortex. Our recent findings suggest that changes in the migratory ability of inhibitory interneurons derived from outside the neocortex may also have been involved in the evolution of the neocortex. In this article we review the literature on the migratory profile of inhibitory interneurons in several different species and the literature on comparisons between the intrinsic migratory ability of interneurons derived from different species. Finally, we propose a hypothesis about the mammalian-specific evolution of the migratory ability of interneurons and its potential contribution to the establishment of a functional neocortex.
| Original language | English |
|---|---|
| Pages (from-to) | 366-372 |
| Number of pages | 7 |
| Journal | Development Growth and Differentiation |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 Apr |
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Keywords
- Cerebral cortex
- Medial ganglionic eminence
- Transplantation
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
Cite this
GABAergic interneuron migration and the evolution of the neocortex. / Tanaka, Daisuke H.; Nakajima, Kazunori.
In: Development Growth and Differentiation, Vol. 54, No. 3, 04.2012, p. 366-372.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - GABAergic interneuron migration and the evolution of the neocortex
AU - Tanaka, Daisuke H.
AU - Nakajima, Kazunori
PY - 2012/4
Y1 - 2012/4
N2 - A neocortex is present in all mammals but is not present in other classes of vertebrates, and the neocortex is extremely elaborate in humans. Changes in excitatory projection neurons and their progenitors within the developing dorsal pallium in the most recent common ancestor of mammals are thought to have been involved in the evolution of the neocortex. Our recent findings suggest that changes in the migratory ability of inhibitory interneurons derived from outside the neocortex may also have been involved in the evolution of the neocortex. In this article we review the literature on the migratory profile of inhibitory interneurons in several different species and the literature on comparisons between the intrinsic migratory ability of interneurons derived from different species. Finally, we propose a hypothesis about the mammalian-specific evolution of the migratory ability of interneurons and its potential contribution to the establishment of a functional neocortex.
AB - A neocortex is present in all mammals but is not present in other classes of vertebrates, and the neocortex is extremely elaborate in humans. Changes in excitatory projection neurons and their progenitors within the developing dorsal pallium in the most recent common ancestor of mammals are thought to have been involved in the evolution of the neocortex. Our recent findings suggest that changes in the migratory ability of inhibitory interneurons derived from outside the neocortex may also have been involved in the evolution of the neocortex. In this article we review the literature on the migratory profile of inhibitory interneurons in several different species and the literature on comparisons between the intrinsic migratory ability of interneurons derived from different species. Finally, we propose a hypothesis about the mammalian-specific evolution of the migratory ability of interneurons and its potential contribution to the establishment of a functional neocortex.
KW - Cerebral cortex
KW - Medial ganglionic eminence
KW - Transplantation
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UR - http://www.scopus.com/inward/citedby.url?scp=84860227341&partnerID=8YFLogxK
U2 - 10.1111/j.1440-169X.2012.01351.x
DO - 10.1111/j.1440-169X.2012.01351.x
M3 - Article
VL - 54
SP - 366
EP - 372
JO - Development, growth & differentiation
JF - Development, growth & differentiation
SN - 0012-1592
IS - 3
ER -