GABAergic interneuron migration and the evolution of the neocortex

Daisuke H. Tanaka, Kazunori Nakajima

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A neocortex is present in all mammals but is not present in other classes of vertebrates, and the neocortex is extremely elaborate in humans. Changes in excitatory projection neurons and their progenitors within the developing dorsal pallium in the most recent common ancestor of mammals are thought to have been involved in the evolution of the neocortex. Our recent findings suggest that changes in the migratory ability of inhibitory interneurons derived from outside the neocortex may also have been involved in the evolution of the neocortex. In this article we review the literature on the migratory profile of inhibitory interneurons in several different species and the literature on comparisons between the intrinsic migratory ability of interneurons derived from different species. Finally, we propose a hypothesis about the mammalian-specific evolution of the migratory ability of interneurons and its potential contribution to the establishment of a functional neocortex.

Original languageEnglish
Pages (from-to)366-372
Number of pages7
JournalDevelopment Growth and Differentiation
Volume54
Issue number3
DOIs
Publication statusPublished - 2012 Apr

Fingerprint

Neocortex
Interneurons
Mammals
Vertebrates
Neurons

Keywords

  • Cerebral cortex
  • Medial ganglionic eminence
  • Transplantation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

GABAergic interneuron migration and the evolution of the neocortex. / Tanaka, Daisuke H.; Nakajima, Kazunori.

In: Development Growth and Differentiation, Vol. 54, No. 3, 04.2012, p. 366-372.

Research output: Contribution to journalArticle

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