Gadolinium-based hybrid nanoparticles as a positive MR contrast agent

Hiroki Hifumi, Seiichi Yamaoka, Akihiro Tanimoto, Daniel Citterio, Koji Suzuki

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

A new nanoparticulate inorganic-organic hybrid-type positive contrast agent (CA), PGP/dextran-K01, was synthesized based on a GdPO4 inorganic core as a relaxation-time-shortening moiety and a dextran-coating, which generates monodispersibility in water, a high relaxation-time-shortening effect by retaining a large number of water molecules in proximity of the core and toxicity reduction in in-vivo studies. This PGP/dextran-K01 nanoparticle has high r1 and r2 values and a significantly low r2/r1 value, 1.1, which is unprecedented and which is the lowest value among existing nanoparticulate CAs indicating that PGP/dextran-K01 is a positive contrast agent. Because of this low r2/r1 value and the nanoparticulate shape, PGP/dextran-K01 will be a useful clinical substitute for negative CAs based on iron oxides.

Original languageEnglish
Pages (from-to)15090-15091
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number47
DOIs
Publication statusPublished - 2006 Nov 29

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Dextran
Gadolinium
Dextrans
Nanoparticles
Contrast Media
Relaxation time
Water
Iron oxides
Toxicity
Coatings
Molecules

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Gadolinium-based hybrid nanoparticles as a positive MR contrast agent. / Hifumi, Hiroki; Yamaoka, Seiichi; Tanimoto, Akihiro; Citterio, Daniel; Suzuki, Koji.

In: Journal of the American Chemical Society, Vol. 128, No. 47, 29.11.2006, p. 15090-15091.

Research output: Contribution to journalArticle

Hifumi, Hiroki ; Yamaoka, Seiichi ; Tanimoto, Akihiro ; Citterio, Daniel ; Suzuki, Koji. / Gadolinium-based hybrid nanoparticles as a positive MR contrast agent. In: Journal of the American Chemical Society. 2006 ; Vol. 128, No. 47. pp. 15090-15091.
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