Galanin-positive nerves of trigeminal origin innervate rat cerebral vessels

Norihiro Suzuki, Jan Erik Hardebo, Jan Kåhrström, Christer Owman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Galanin (GAL)-positive nerve fibers in rat cerebral vessels were demonstrated by immunohistochemistry, and their origin in the trigeminal ganglia and pathway in the nasociliary nerve to the vessels was shown by retrograde tracer technique and nerve transection. Some fibers in the vertebrobasilar system appear to originate in extracranial sources. With the antiserum used only few GAL fibers could be seen in the vessels, mostly in the vertebrobasilar system. In neonatally sympathectomized animals a rich network could be visualized in most pial arteries - still particularly in the vertebrobasilar system - probably as a result of a diminished competition for nerve growth factor. No vasomotor effect of GAL could be detected in isolated segments of pial arteries, neither in normal nor in sympathectomized animals, which rules out a direct postsynaptic effect on vascular tone. GAL did not display prejunctional modulatory action on the adrenergic nerves present in the vascular preparations. A sensory function of GAL is discussed.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalNeuroscience Letters
Volume100
Issue number1-3
DOIs
Publication statusPublished - 1989 May 22
Externally publishedYes

Fingerprint

Galanin
Trigeminal Nerve
Blood Vessels
Arteries
Trigeminal Ganglion
Nerve Growth Factor
Nerve Fibers
Adrenergic Agents
Immune Sera
Immunohistochemistry

Keywords

  • Cerebral vessel
  • Galanin
  • Immunohistochemistry
  • Neuropeptide
  • Sensory nerve fiber
  • Sympathectomy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Galanin-positive nerves of trigeminal origin innervate rat cerebral vessels. / Suzuki, Norihiro; Hardebo, Jan Erik; Kåhrström, Jan; Owman, Christer.

In: Neuroscience Letters, Vol. 100, No. 1-3, 22.05.1989, p. 123-129.

Research output: Contribution to journalArticle

Suzuki, N, Hardebo, JE, Kåhrström, J & Owman, C 1989, 'Galanin-positive nerves of trigeminal origin innervate rat cerebral vessels', Neuroscience Letters, vol. 100, no. 1-3, pp. 123-129. https://doi.org/10.1016/0304-3940(89)90671-X
Suzuki, Norihiro ; Hardebo, Jan Erik ; Kåhrström, Jan ; Owman, Christer. / Galanin-positive nerves of trigeminal origin innervate rat cerebral vessels. In: Neuroscience Letters. 1989 ; Vol. 100, No. 1-3. pp. 123-129.
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