Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

Pablo Argüeso, Jerome Mauris, Yuichi Uchino

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalTissue Barriers
Volume3
Issue number3
DOIs
Publication statusPublished - 2015 Jul 3
Externally publishedYes

Fingerprint

Galectin 3
Adhesives
Repair
Tissue
Cell signaling
Galactosides
Cell Physiological Phenomena
Physiology
Wounds and Injuries
Wound Healing
Modulators
Extracellular Matrix
Tumors
Neoplasms
Epithelial Cells
saccharide-binding proteins

Keywords

  • cancer
  • epithelial junction
  • galectin-3
  • matrix metalloproteinases
  • wound healing

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Histology

Cite this

Galectin-3 as a regulator of the epithelial junction : Implications to wound repair and cancer. / Argüeso, Pablo; Mauris, Jerome; Uchino, Yuichi.

In: Tissue Barriers, Vol. 3, No. 3, 03.07.2015, p. 1-6.

Research output: Contribution to journalArticle

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