Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice

Chiyoko Nishime, Yasuyuki Ohnishi, Hiroshi Suemizu, Norikazu Tamaoki, Makoto Suematsu, Yasuhisa Oida, Hitoshi Yamazaki, Masato Nakamura, Yoshito Ueyama, Hiroshi Kijima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalAnticancer Research
Volume26
Issue number1 A
Publication statusPublished - 2006 Jan

Fingerprint

Small Cell Carcinoma
Gallbladder
Heterografts
Nude Mice
Transplantation
Carcinoma
Neoplasms
Chromatin
Electrons
Membranes

Keywords

  • Gallbladder cancer
  • Immunohistochemistry
  • Small cell carcinoma
  • Xenograft

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nishime, C., Ohnishi, Y., Suemizu, H., Tamaoki, N., Suematsu, M., Oida, Y., ... Kijima, H. (2006). Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice. Anticancer Research, 26(1 A), 79-83.

Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice. / Nishime, Chiyoko; Ohnishi, Yasuyuki; Suemizu, Hiroshi; Tamaoki, Norikazu; Suematsu, Makoto; Oida, Yasuhisa; Yamazaki, Hitoshi; Nakamura, Masato; Ueyama, Yoshito; Kijima, Hiroshi.

In: Anticancer Research, Vol. 26, No. 1 A, 01.2006, p. 79-83.

Research output: Contribution to journalArticle

Nishime, C, Ohnishi, Y, Suemizu, H, Tamaoki, N, Suematsu, M, Oida, Y, Yamazaki, H, Nakamura, M, Ueyama, Y & Kijima, H 2006, 'Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice', Anticancer Research, vol. 26, no. 1 A, pp. 79-83.
Nishime C, Ohnishi Y, Suemizu H, Tamaoki N, Suematsu M, Oida Y et al. Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice. Anticancer Research. 2006 Jan;26(1 A):79-83.
Nishime, Chiyoko ; Ohnishi, Yasuyuki ; Suemizu, Hiroshi ; Tamaoki, Norikazu ; Suematsu, Makoto ; Oida, Yasuhisa ; Yamazaki, Hitoshi ; Nakamura, Masato ; Ueyama, Yoshito ; Kijima, Hiroshi. / Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice. In: Anticancer Research. 2006 ; Vol. 26, No. 1 A. pp. 79-83.
@article{18c3660ea8e54460867963a2bca98ca1,
title = "Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice",
abstract = "The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.",
keywords = "Gallbladder cancer, Immunohistochemistry, Small cell carcinoma, Xenograft",
author = "Chiyoko Nishime and Yasuyuki Ohnishi and Hiroshi Suemizu and Norikazu Tamaoki and Makoto Suematsu and Yasuhisa Oida and Hitoshi Yamazaki and Masato Nakamura and Yoshito Ueyama and Hiroshi Kijima",
year = "2006",
month = "1",
language = "English",
volume = "26",
pages = "79--83",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1 A",

}

TY - JOUR

T1 - Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice

AU - Nishime, Chiyoko

AU - Ohnishi, Yasuyuki

AU - Suemizu, Hiroshi

AU - Tamaoki, Norikazu

AU - Suematsu, Makoto

AU - Oida, Yasuhisa

AU - Yamazaki, Hitoshi

AU - Nakamura, Masato

AU - Ueyama, Yoshito

AU - Kijima, Hiroshi

PY - 2006/1

Y1 - 2006/1

N2 - The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.

AB - The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.

KW - Gallbladder cancer

KW - Immunohistochemistry

KW - Small cell carcinoma

KW - Xenograft

UR - http://www.scopus.com/inward/record.url?scp=32144437991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32144437991&partnerID=8YFLogxK

M3 - Article

C2 - 16475682

AN - SCOPUS:32144437991

VL - 26

SP - 79

EP - 83

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 1 A

ER -