Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice

Chiyoko Nishime; Yasuyuki Ohnishi; Hiroshi Suemizu; Norikazu Tamaoki; Makoto Suematsu; Yasuhisa Oida; Hitoshi Yamazaki; Masato Nakamura; Yoshito Ueyama; Hiroshi Kijima

Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice

Chiyoko Nishime, Yasuyuki Ohnishi, Hiroshi Suemizu, Norikazu Tamaoki, Makoto Suematsu, Yasuhisa Oida, Hitoshi Yamazaki, Masato Nakamura, Yoshito Ueyama, Hiroshi Kijima

Department of Biochemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	Anticancer research
Volume	26
Issue number	1 A
Publication status	Published - 2006 Jan 1

Keywords

Gallbladder cancer
Immunohistochemistry
Small cell carcinoma
Xenograft

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice",

abstract = "The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.",

keywords = "Gallbladder cancer, Immunohistochemistry, Small cell carcinoma, Xenograft",

author = "Chiyoko Nishime and Yasuyuki Ohnishi and Hiroshi Suemizu and Norikazu Tamaoki and Makoto Suematsu and Yasuhisa Oida and Hitoshi Yamazaki and Masato Nakamura and Yoshito Ueyama and Hiroshi Kijima",

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day = "1",

language = "English",

volume = "26",

pages = "79--83",

journal = "Anticancer Research",

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publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice

AU - Nishime, Chiyoko

AU - Ohnishi, Yasuyuki

AU - Suemizu, Hiroshi

AU - Tamaoki, Norikazu

AU - Suematsu, Makoto

AU - Oida, Yasuhisa

AU - Yamazaki, Hitoshi

AU - Nakamura, Masato

AU - Ueyama, Yoshito

AU - Kijima, Hiroshi

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.

AB - The GB-04-JCK xenograft line of human gallbladder small cell carcinoma was established in nude mice by serial transplantation. The xenotransplantability has been maintained for more than 20 years. The carcinoma cells grew in a solid-sheet pattern and were found to have hyperchromatic nuclei, finely dispersed chromatin and inconspicuous nucleoli in the primary gallbladder tumor, as well as in the established xenograft GB-04-JCK. The carcinoma cells also had Grimelius argyrophil granules, electron-dense neuroendocrine granules bounded by a single membrane. The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma.

KW - Gallbladder cancer

KW - Immunohistochemistry

KW - Small cell carcinoma

KW - Xenograft

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M3 - Article

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AN - SCOPUS:32144437991

SN - 0250-7005

VL - 26

SP - 79

EP - 83

JO - Anticancer Research

JF - Anticancer Research

IS - 1 A

ER -

Gallbladder small cell carcinoma xenograft established by serial transplantation in nude mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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