Ganglioside-binding Peptides selected from a Combinatorial Library and Their Carbohydrate Recognition

Proteins such as lectins, enzymes, and antibodies, have been employed in the investigation of protein-carbohydrate interaction. However, it is very difficult to design molecules that bind specifically to a target carbohydrate. In my study, selection of ganglioside-binding peptides from a combinatorial random peptide library was carried out. The selected peptides specifically bound to the ganglioside and were suggested to have interacted with carbohydrate through a consensus motif.