Ganglioside-binding Peptides selected from a Combinatorial Library and Their Carbohydrate Recognition

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Abstract

Proteins such as lectins, enzymes, and antibodies, have been employed in the investigation of protein-carbohydrate interaction. However, it is very difficult to design molecules that bind specifically to a target carbohydrate. In my study, selection of ganglioside-binding peptides from a combinatorial random peptide library was carried out. The selected peptides specifically bound to the ganglioside and were suggested to have interacted with carbohydrate through a consensus motif.

Original languageEnglish
Number of pages1
JournalTrends in Glycoscience and Glycotechnology
Volume13
Issue number73
DOIs
Publication statusPublished - 2001 Sep
Externally publishedYes

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Keywords

  • Carbohydrate recognition
  • Ganglioside
  • Peptide library
  • Phage display

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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