Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins

Takumi Yamaguchi, Tsuyoshi Uno, Yoshinori Uekusa, Maho Yagi-Utsumi, Koichi Kato

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of α-synuclein as a therapeutic target by NMR spectroscopy.

Original languageEnglish
Pages (from-to)1235-1237
Number of pages3
JournalChemical Communications
Volume49
Issue number12
DOIs
Publication statusPublished - 2013 Jan 1

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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