TY - GEN
T1 - Gas-Flow Device for Effective Dissolution of Gas-Phase Odorants Utilized for Biohybrid Sensors
AU - Nakane, Takuma
AU - Osaki, Toshihisa
AU - Mimura, Hisatoshi
AU - Takamori, Sho
AU - Miki, Norihisa
AU - Takeuchi, Shoji
N1 - Funding Information:
This work was partly supported by JSPS KAKENHI Grant Number JP21H05013, and the Program for Building Regional Innovation Ecosystem of MEXT, Japan.
Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - This study describes a gas-flow device that enhances the solubility of gas-phase odorants into aqueous solution for cell-based sensors. Cell-based sensors using olfactory receptors have attracted attention because of their high sensitivity and selectivity. However, most of previous studies used liquid-phase odorants as a target sample due to their low solubility of gas-phase odorants even though the applications expect the gas-phase sensing. Therefore, we focus on gas-phase odorant detection using the gas-flow device. Here, we clarify the impact of the velocity of convection inside the solution to enhancement of the solubility, based on computational simulation. Moreover, we experimentally verify efficiency of odorant dissolution in two types of devices, compared with the negative control using a sample odorant.
AB - This study describes a gas-flow device that enhances the solubility of gas-phase odorants into aqueous solution for cell-based sensors. Cell-based sensors using olfactory receptors have attracted attention because of their high sensitivity and selectivity. However, most of previous studies used liquid-phase odorants as a target sample due to their low solubility of gas-phase odorants even though the applications expect the gas-phase sensing. Therefore, we focus on gas-phase odorant detection using the gas-flow device. Here, we clarify the impact of the velocity of convection inside the solution to enhancement of the solubility, based on computational simulation. Moreover, we experimentally verify efficiency of odorant dissolution in two types of devices, compared with the negative control using a sample odorant.
KW - Biohybrid sensor
KW - Cell-based sensor
KW - Gas sensor
KW - Gas-flow channel
KW - Gas-phase odorant
KW - Olfactory receptor
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U2 - 10.1109/MEMS49605.2023.10052624
DO - 10.1109/MEMS49605.2023.10052624
M3 - Conference contribution
AN - SCOPUS:85149886270
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 293
EP - 294
BT - 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 36th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2023
Y2 - 15 January 2023 through 19 January 2023
ER -