Gastric carcinogenesis and underlying molecular mechanisms

Helicobacter pylori and novel targeted therapy

Toshihiro Nishizawa, Hidekazu Suzuki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The oxygen-derived free radicals that are released from activated neutrophils are one of the cytotoxic factors of Helicobacter pylori-induced gastric mucosal injury. Increased cytidine deaminase activity in H. pylori-infected gastric tissues promotes the accumulation of various mutations and might promote gastric carcinogenesis. Cytotoxin-associated gene A (CagA) is delivered into gastric epithelial cells via bacterial type IV secretion system, and it causes inflammation and activation of oncogenic pathways. H. pylori infection induces epigenetic transformations, such as aberrant promoter methylation in tumor-suppressor genes. Aberrant expression of microRNAs is also reportedly linked to gastric tumorogenesis. Moreover, recent advances in molecular targeting therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2 (HER-2) therapies. This updated review article highlights possible mechanisms of gastric carcinogenesis including H. pylori-associated factors.

Original languageEnglish
Article number794378
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Helicobacter pylori
Stomach
Carcinogenesis
Genes
Cytidine Deaminase
Methylation
Cytotoxins
MicroRNAs
Free Radicals
Tumors
Chemical activation
Tissue
Oxygen
Therapeutics
Weapons
Helicobacter Infections
Tumor Suppressor Genes
Epigenomics
Stomach Neoplasms
Neutrophils

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Gastric carcinogenesis and underlying molecular mechanisms : Helicobacter pylori and novel targeted therapy. / Nishizawa, Toshihiro; Suzuki, Hidekazu.

In: BioMed Research International, Vol. 2015, 794378, 2015.

Research output: Contribution to journalArticle

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