Gastric non-helicobacter pylori helicobacter: Its significance in human gastric diseases

Masahiko Nakamura, Anders Øverby, Somay Y. Murayama, Hidekazu Suzuki, Tetsufumi Takahashi, Shinichi Takahashi, Hidenori Matsui

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

In the post-H. pylori eradication era, the clinical significance of gastric non-H. pylori helicobacters (NHPH; also referred to as H. heilmannii-like organisms and H. heilmannii sensu lato) is gradually increasing. This group of bacteria may inhabit the stomach of domestic and wild animals including cats, dogs, pigs, primates, rodents, cheetahs, and rabbits. NHPH are zoonotic microorganisms, meaning that they may transmit between animals and humans. They may be distinguished from H. pylori regarding their microbiology involving larger cells with more distinct spiral shape and bipolarity, localization in the stomach layer and regional distribution, urease activity and virulence factors, and relation to gastric diseases where gastric NHPH infection is often associated with milder gastritis than H. pylori but higher risk of gastric MALT lymphoma. At present, pure culture of NHPH species remains a challenge, but the full genome sequences of some of the species have been reported. Recent and ongoing prevalence studies indicate a higher clinical relevance of these bacteria than earlier impressions suggested. Current efforts in improving cultivation and detection methodology are contributing to an increased understanding of their microbiology, prevalence, and relevance to human diseases.

Original languageEnglish
Title of host publicationHelicobacter Pylori
PublisherSpringer Japan
Pages131-140
Number of pages10
ISBN (Electronic)9784431557050
ISBN (Print)9784431557043
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Stomach Diseases
Helicobacter pylori
Stomach
Microbiology
Acinonyx
Bacteria
Marginal Zone B-Cell Lymphoma
Wild Animals
Urease
Domestic Animals
Zoonoses
Virulence Factors
Gastritis
Primates
Rodentia
Cats
Swine
Cross-Sectional Studies
Genome
Dogs

Keywords

  • Helicobacter heilmannii
  • Helicobacter suis
  • Non-Helicobacter pylori helicobacter
  • Zoonosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nakamura, M., Øverby, A., Murayama, S. Y., Suzuki, H., Takahashi, T., Takahashi, S., & Matsui, H. (2016). Gastric non-helicobacter pylori helicobacter: Its significance in human gastric diseases. In Helicobacter Pylori (pp. 131-140). Springer Japan. https://doi.org/10.1007/978-4-431-55705-0_8

Gastric non-helicobacter pylori helicobacter : Its significance in human gastric diseases. / Nakamura, Masahiko; Øverby, Anders; Murayama, Somay Y.; Suzuki, Hidekazu; Takahashi, Tetsufumi; Takahashi, Shinichi; Matsui, Hidenori.

Helicobacter Pylori. Springer Japan, 2016. p. 131-140.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nakamura, M, Øverby, A, Murayama, SY, Suzuki, H, Takahashi, T, Takahashi, S & Matsui, H 2016, Gastric non-helicobacter pylori helicobacter: Its significance in human gastric diseases. in Helicobacter Pylori. Springer Japan, pp. 131-140. https://doi.org/10.1007/978-4-431-55705-0_8
Nakamura M, Øverby A, Murayama SY, Suzuki H, Takahashi T, Takahashi S et al. Gastric non-helicobacter pylori helicobacter: Its significance in human gastric diseases. In Helicobacter Pylori. Springer Japan. 2016. p. 131-140 https://doi.org/10.1007/978-4-431-55705-0_8
Nakamura, Masahiko ; Øverby, Anders ; Murayama, Somay Y. ; Suzuki, Hidekazu ; Takahashi, Tetsufumi ; Takahashi, Shinichi ; Matsui, Hidenori. / Gastric non-helicobacter pylori helicobacter : Its significance in human gastric diseases. Helicobacter Pylori. Springer Japan, 2016. pp. 131-140
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