Gastrointestinal hormones and regulation of gastric emptying

Hideki Mori, Wout Verbeure, Jolien Schol, Florencia Carbone, Jan Tack

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Purpose of reviewIn this review, we evaluate recent findings related to the association between gastrointestinal hormones and regulation of gastric emptying.Recent findingsMotilin and ghrelin, which act during fasting, promote gastric motility, whereas most of the hormones secreted after a meal inhibit gastric motility. Serotonin has different progastric or antigastric motility effects depending on the receptor subtype. Serotonin receptor agonists have been used clinically to treat dyspepsia symptoms but other hormone receptor agonists or antagonists are still under development. Glucagon-like peptide 1 agonists, which have gastric motility and appetite-suppressing effects are used as a treatment for obesity and diabetes.SummaryGastrointestinal hormones play an important role in the regulation of gastric motility. Various drugs have been developed to treat delayed gastric emptying by targeting gastrointestinal hormones or their receptors but few have been commercialized.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume29
Issue number2
DOIs
Publication statusPublished - 2022 Apr 1
Externally publishedYes

Keywords

  • cholecystokinin
  • ghrelin
  • glucagon-like peptide 1
  • motilin
  • serotonin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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