Gatifloxacin resistance and mutations in gyrA after unsuccessful Helicobacter pylori eradication in Japan

Toshihiro Nishizawa, Hidekazu Suzuki, Kumiko Kurabayashi, Tatsuhiro Masaoka, Hiroe Muraoka, Mikiji Mori, Eisuke Iwasaki, Intetsu Kobayashi, Toshifumi Hibi

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 μg/ml and mutations of the gyrA gene of H. pylori was demonstrated.

Original languageEnglish
Pages (from-to)1538-1540
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number4
DOIs
Publication statusPublished - 2006 Apr

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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