Gatifloxacin resistance and mutations in gyrA after unsuccessful Helicobacter pylori eradication in Japan

Toshihiro Nishizawa, Hidekazu Suzuki, Kumiko Kurabayashi, Tatsuhiro Masaoka, Hiroe Muraoka, Mikiji Mori, Eisuke Iwasaki, Intetsu Kobayashi, Toshifumi Hibi

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

A high resistance rate (47.9%) to gatifloxacin (GAT; 8-methoxy fluoroquinolone) in Helicobacter pylori (H. pylori) strains from 48 Japanese patients is observed after unsuccessful H. pylori eradication. A significant association between MICs for GAT equal to or above 1 μg/ml and mutations of the gyrA gene of H. pylori was demonstrated.

Original languageEnglish
Pages (from-to)1538-1540
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number4
DOIs
Publication statusPublished - 2006 Apr

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Helicobacter pylori
Japan
Mutation
Fluoroquinolones
Genes
gatifloxacin
GAT

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Gatifloxacin resistance and mutations in gyrA after unsuccessful Helicobacter pylori eradication in Japan. / Nishizawa, Toshihiro; Suzuki, Hidekazu; Kurabayashi, Kumiko; Masaoka, Tatsuhiro; Muraoka, Hiroe; Mori, Mikiji; Iwasaki, Eisuke; Kobayashi, Intetsu; Hibi, Toshifumi.

In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 4, 04.2006, p. 1538-1540.

Research output: Contribution to journalArticle

Nishizawa, Toshihiro ; Suzuki, Hidekazu ; Kurabayashi, Kumiko ; Masaoka, Tatsuhiro ; Muraoka, Hiroe ; Mori, Mikiji ; Iwasaki, Eisuke ; Kobayashi, Intetsu ; Hibi, Toshifumi. / Gatifloxacin resistance and mutations in gyrA after unsuccessful Helicobacter pylori eradication in Japan. In: Antimicrobial Agents and Chemotherapy. 2006 ; Vol. 50, No. 4. pp. 1538-1540.
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AU - Masaoka, Tatsuhiro

AU - Muraoka, Hiroe

AU - Mori, Mikiji

AU - Iwasaki, Eisuke

AU - Kobayashi, Intetsu

AU - Hibi, Toshifumi

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