TY - JOUR
T1 - Gender differences in in-hospital clinical outcomes after percutaneous coronary interventions
T2 - An insight from a Japanese multicenter registry
AU - Numasawa, Yohei
AU - Kohsaka, Shun
AU - Miyata, Hiroaki
AU - Noma, Shigetaka
AU - Suzuki, Masahiro
AU - Ishikawa, Shiro
AU - Nakamura, Iwao
AU - Nishi, Yutaro
AU - Ohki, Takahiro
AU - Negishi, Koji
AU - Takahashi, Toshiyuki
AU - Fukuda, Keiichi
N1 - Publisher Copyright:
© 2015 Numasawa et al.
PY - 2015/1/30
Y1 - 2015/1/30
N2 - Background: Gender differences in clinical outcomes after percutaneous coronary intervention (PCI) among different age groups are controversial in the era of drug-eluting stents, especially among the Asian population who are at higher risk for bleeding complications. Methods and Results: We analyzed data from 10,220 patients who underwent PCI procedures performed at 14 Japanese hospitals from September 2008 to April 2013. A total of 2,106 (20.6%) patients were women. Women were older (72.7±9.7 vs 66.6±10.8 years, p< 0.001), and had a lower body mass index (23.4±4.0 vs 24.3±3.5, p<0.001), with a higher prevalence of hypertension (p<0.001), hyperlipidemia (p<0.001), insulin-dependent diabetes (p<0.001), renal failure (p<0.001), and heart failure (p<0.001) compared with men. Men tended to have more bifurcation lesions (p = 0.003) and chronic totally occluded lesions (p<0.001) than women. Crude overall complications (14.8% vs 9.5%, p<0.001) and the rate of bleeding complications (5.3% vs 2.8%, p<0.001) were significantly higher in women than in men. On multivariate analysis in the total cohort, female sex was an independent predictor of overall complications (OR, 1.47; 95% CI, 1.26 -1.71; p<0.001) and bleeding complications (OR, 1.74; 95% CI, 1.36-2.24; p<0.001) after adjustment for confounding variables. A similar trend was observed across the middle-aged group (≥55 and <75 years) and old age group (≥75 years). Conclusions: Women are at higher risk than men for post-procedural complications after PCI, regardless of age.
AB - Background: Gender differences in clinical outcomes after percutaneous coronary intervention (PCI) among different age groups are controversial in the era of drug-eluting stents, especially among the Asian population who are at higher risk for bleeding complications. Methods and Results: We analyzed data from 10,220 patients who underwent PCI procedures performed at 14 Japanese hospitals from September 2008 to April 2013. A total of 2,106 (20.6%) patients were women. Women were older (72.7±9.7 vs 66.6±10.8 years, p< 0.001), and had a lower body mass index (23.4±4.0 vs 24.3±3.5, p<0.001), with a higher prevalence of hypertension (p<0.001), hyperlipidemia (p<0.001), insulin-dependent diabetes (p<0.001), renal failure (p<0.001), and heart failure (p<0.001) compared with men. Men tended to have more bifurcation lesions (p = 0.003) and chronic totally occluded lesions (p<0.001) than women. Crude overall complications (14.8% vs 9.5%, p<0.001) and the rate of bleeding complications (5.3% vs 2.8%, p<0.001) were significantly higher in women than in men. On multivariate analysis in the total cohort, female sex was an independent predictor of overall complications (OR, 1.47; 95% CI, 1.26 -1.71; p<0.001) and bleeding complications (OR, 1.74; 95% CI, 1.36-2.24; p<0.001) after adjustment for confounding variables. A similar trend was observed across the middle-aged group (≥55 and <75 years) and old age group (≥75 years). Conclusions: Women are at higher risk than men for post-procedural complications after PCI, regardless of age.
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U2 - 10.1371/journal.pone.0116496
DO - 10.1371/journal.pone.0116496
M3 - Article
C2 - 25635905
AN - SCOPUS:84961291912
VL - 10
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 1
M1 - e0116496
ER -