Gene expression of MMPs and TIMPs in the process of hepatic fibrosis

I. Okazaki, M. Arai, Norihito Wada, K. Maruyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The matrix metalloproteinases (MMPs) gene family includes MMP-1 (interstitial collagenase), MMP-2 (72 kD type IV collagenase/gelatinase), MMP-3 (stromelysin/transin), MMP-7 (putative MMP; pump-1), MMP-8 (granulocyte collagenase) and MMP-9 (92 kD type IV collagenase/gelatinase). This gene family has the common characteristics in the gene structure as follows: All of MMPs have the active site metal ion-binding domain. All six enzymes are activated with the concomitant removal of N-terminal segment of the latent enzyme. The removed segment contains an unpaired cystein residue within the conserved amino acid sequence PRCGVPDV, located immediately adjacent to the proenzyme cleavage site. The authors showed the gene expression of MMP-1 in the process of hepatic fibrosis. The remarkable expression was noted on fibroblasts and macrophages within the newly-formed fibrous bands with lots of infiltrated lymphocytes. Liver cirrhosis did not showed the positive dots of MMP-1 mRNA. On the other hands, the expression of TIMP reported by Takahara et al., revealed the high level of expression in the advanced fibrosis.

Original languageEnglish
Pages (from-to)428-434
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume51
Issue number2
Publication statusPublished - 1993 Feb
Externally publishedYes

Fingerprint

Matrix Metalloproteinase 1
Matrix Metalloproteinases
Fibrosis
Matrix Metalloproteinase 3
Gene Expression
Collagenases
Liver
Gelatinases
Matrix Metalloproteinase 7
Matrix Metalloproteinase 8
Genes
Enzyme Precursors
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Enzymes
Granulocytes
Liver Cirrhosis
Amino Acid Sequence
Catalytic Domain
Fibroblasts

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gene expression of MMPs and TIMPs in the process of hepatic fibrosis. / Okazaki, I.; Arai, M.; Wada, Norihito; Maruyama, K.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 51, No. 2, 02.1993, p. 428-434.

Research output: Contribution to journalArticle

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