Gene rearrangement studies on lymphoma of the lung: Report of a case

Teruhiro Aoki, Masazumi Watanabe, Keigo Takagi, Susumu Tanaka, Shinsuke Aida

Research output: Contribution to journalArticle

Abstract

We describe herein how true lymphoma of the lung was differentiated from pseudolymphoma in a 45-year-old woman presenting with pulmonary infiltrates. Although segmental resection revealed typical histologic findings of pseudolymphoma of the lung and immunohistochemical studies did not demonstrate a monoclonal proliferation, Southern blot analysis of the frozen tissue revealed rearrangements in the heavy and light chains of the immunoglobulin gene, with no T-cell receptor gene rearrangement suggestive of a lymphoproliferative disorder. These findings indicate that the identification of gene rearrangement may be utilized to distinguish between true lymphoma and pseudolymphoma.

Original languageEnglish
Pages (from-to)281-283
Number of pages3
JournalSurgery Today
Volume25
Issue number3
DOIs
Publication statusPublished - 1995 Mar
Externally publishedYes

Fingerprint

Pseudolymphoma
Gene Rearrangement
Lymphoma
Lung
T-Lymphocyte Gene Rearrangement
Immunoglobulin Light Chains
T-Cell Receptor Genes
Immunoglobulin Heavy Chains
Immunoglobulin Genes
Lymphoproliferative Disorders
Southern Blotting

Keywords

  • gene rearrangement
  • lymphoma
  • pseudolymphoma
  • Southern blot

ASJC Scopus subject areas

  • Surgery

Cite this

Aoki, T., Watanabe, M., Takagi, K., Tanaka, S., & Aida, S. (1995). Gene rearrangement studies on lymphoma of the lung: Report of a case. Surgery Today, 25(3), 281-283. https://doi.org/10.1007/BF00311544

Gene rearrangement studies on lymphoma of the lung : Report of a case. / Aoki, Teruhiro; Watanabe, Masazumi; Takagi, Keigo; Tanaka, Susumu; Aida, Shinsuke.

In: Surgery Today, Vol. 25, No. 3, 03.1995, p. 281-283.

Research output: Contribution to journalArticle

Aoki, T, Watanabe, M, Takagi, K, Tanaka, S & Aida, S 1995, 'Gene rearrangement studies on lymphoma of the lung: Report of a case', Surgery Today, vol. 25, no. 3, pp. 281-283. https://doi.org/10.1007/BF00311544
Aoki, Teruhiro ; Watanabe, Masazumi ; Takagi, Keigo ; Tanaka, Susumu ; Aida, Shinsuke. / Gene rearrangement studies on lymphoma of the lung : Report of a case. In: Surgery Today. 1995 ; Vol. 25, No. 3. pp. 281-283.
@article{e7b2b87821d149dc8456cff34720d1c0,
title = "Gene rearrangement studies on lymphoma of the lung: Report of a case",
abstract = "We describe herein how true lymphoma of the lung was differentiated from pseudolymphoma in a 45-year-old woman presenting with pulmonary infiltrates. Although segmental resection revealed typical histologic findings of pseudolymphoma of the lung and immunohistochemical studies did not demonstrate a monoclonal proliferation, Southern blot analysis of the frozen tissue revealed rearrangements in the heavy and light chains of the immunoglobulin gene, with no T-cell receptor gene rearrangement suggestive of a lymphoproliferative disorder. These findings indicate that the identification of gene rearrangement may be utilized to distinguish between true lymphoma and pseudolymphoma.",
keywords = "gene rearrangement, lymphoma, pseudolymphoma, Southern blot",
author = "Teruhiro Aoki and Masazumi Watanabe and Keigo Takagi and Susumu Tanaka and Shinsuke Aida",
year = "1995",
month = "3",
doi = "10.1007/BF00311544",
language = "English",
volume = "25",
pages = "281--283",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Gene rearrangement studies on lymphoma of the lung

T2 - Report of a case

AU - Aoki, Teruhiro

AU - Watanabe, Masazumi

AU - Takagi, Keigo

AU - Tanaka, Susumu

AU - Aida, Shinsuke

PY - 1995/3

Y1 - 1995/3

N2 - We describe herein how true lymphoma of the lung was differentiated from pseudolymphoma in a 45-year-old woman presenting with pulmonary infiltrates. Although segmental resection revealed typical histologic findings of pseudolymphoma of the lung and immunohistochemical studies did not demonstrate a monoclonal proliferation, Southern blot analysis of the frozen tissue revealed rearrangements in the heavy and light chains of the immunoglobulin gene, with no T-cell receptor gene rearrangement suggestive of a lymphoproliferative disorder. These findings indicate that the identification of gene rearrangement may be utilized to distinguish between true lymphoma and pseudolymphoma.

AB - We describe herein how true lymphoma of the lung was differentiated from pseudolymphoma in a 45-year-old woman presenting with pulmonary infiltrates. Although segmental resection revealed typical histologic findings of pseudolymphoma of the lung and immunohistochemical studies did not demonstrate a monoclonal proliferation, Southern blot analysis of the frozen tissue revealed rearrangements in the heavy and light chains of the immunoglobulin gene, with no T-cell receptor gene rearrangement suggestive of a lymphoproliferative disorder. These findings indicate that the identification of gene rearrangement may be utilized to distinguish between true lymphoma and pseudolymphoma.

KW - gene rearrangement

KW - lymphoma

KW - pseudolymphoma

KW - Southern blot

UR - http://www.scopus.com/inward/record.url?scp=0029063734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029063734&partnerID=8YFLogxK

U2 - 10.1007/BF00311544

DO - 10.1007/BF00311544

M3 - Article

C2 - 7640463

AN - SCOPUS:0029063734

VL - 25

SP - 281

EP - 283

JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

IS - 3

ER -