Gene rearrangement studies on lymphoma of the lung: Report of a case

Teruhiro Aoki, Masazumi Watanabe, Keigo Takagi, Susumu Tanaka, Shinsuke Aida

Research output: Contribution to journalArticlepeer-review

Abstract

We describe herein how true lymphoma of the lung was differentiated from pseudolymphoma in a 45-year-old woman presenting with pulmonary infiltrates. Although segmental resection revealed typical histologic findings of pseudolymphoma of the lung and immunohistochemical studies did not demonstrate a monoclonal proliferation, Southern blot analysis of the frozen tissue revealed rearrangements in the heavy and light chains of the immunoglobulin gene, with no T-cell receptor gene rearrangement suggestive of a lymphoproliferative disorder. These findings indicate that the identification of gene rearrangement may be utilized to distinguish between true lymphoma and pseudolymphoma.

Original languageEnglish
Pages (from-to)281-283
Number of pages3
JournalSurgery today
Volume25
Issue number3
DOIs
Publication statusPublished - 1995 Mar 1

Keywords

  • Southern blot
  • gene rearrangement
  • lymphoma
  • pseudolymphoma

ASJC Scopus subject areas

  • Surgery

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