Gene therapy for breast cancer. — review of clinical gene therapy trials for breast cancer and mdr1 gene therapy trial in cancer institute hospital

Shunji Takahashi; Yoshinori Ito; Kiyohiko Hatake; Yoshikazu Sugimoto

doi:10.2325/jbcs.13.8

Gene therapy for breast cancer. — review of clinical gene therapy trials for breast cancer and mdr1 gene therapy trial in cancer institute hospital

Shunji Takahashi, Yoshinori Ito, Kiyohiko Hatake, Yoshikazu Sugimoto

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

Gene therapy for advanced breast cancer is anticipated to be a useful therapeutic approach. Strategies in ongoing clinical protocols can be divided into four groups: (1) suppression of oncogenes or transfer of tumor-suppressor genes; (2) enhancement of immunological response; (3) transfer of suicide genes; (4) protection of bone marrow using drug resistance genes. We have started a clinical study of multidrug resistance (MDRl) gene therapy. Advanced breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) withMDRl-transduced hematopoietic cells, and then were treated with docetaxel. Two patients have been treated so far, andin vivo enrichment ofMDRl-transduced cells with docetaxel treatment has been seen. Both patients are in complete remission and had no apparent adverse effects from theMDRl gene transfer.

Original language	English
Pages (from-to)	8-15
Number of pages	8
Journal	Breast Cancer
Volume	13
Issue number	1
DOIs	https://doi.org/10.2325/jbcs.13.8
Publication status	Published - 2006 Jan

Keywords

Adenoviral vector
Breast cancer
Gene therapy
MDRl
Retroviral vector

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2325/jbcs.13.8

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title = "Gene therapy for breast cancer. — review of clinical gene therapy trials for breast cancer and mdr1 gene therapy trial in cancer institute hospital",

abstract = "Gene therapy for advanced breast cancer is anticipated to be a useful therapeutic approach. Strategies in ongoing clinical protocols can be divided into four groups: (1) suppression of oncogenes or transfer of tumor-suppressor genes; (2) enhancement of immunological response; (3) transfer of suicide genes; (4) protection of bone marrow using drug resistance genes. We have started a clinical study of multidrug resistance (MDRl) gene therapy. Advanced breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) withMDRl-transduced hematopoietic cells, and then were treated with docetaxel. Two patients have been treated so far, andin vivo enrichment ofMDRl-transduced cells with docetaxel treatment has been seen. Both patients are in complete remission and had no apparent adverse effects from theMDRl gene transfer.",

keywords = "Adenoviral vector, Breast cancer, Gene therapy, MDRl, Retroviral vector",

author = "Shunji Takahashi and Yoshinori Ito and Kiyohiko Hatake and Yoshikazu Sugimoto",

note = "Funding Information: This work was supported by the grants from the Min- Publisher Copyright: {\textcopyright} 2006, The Japanese Breast Cancer Society.",

year = "2006",

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AU - Hatake, Kiyohiko

AU - Sugimoto, Yoshikazu

PY - 2006/1

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AB - Gene therapy for advanced breast cancer is anticipated to be a useful therapeutic approach. Strategies in ongoing clinical protocols can be divided into four groups: (1) suppression of oncogenes or transfer of tumor-suppressor genes; (2) enhancement of immunological response; (3) transfer of suicide genes; (4) protection of bone marrow using drug resistance genes. We have started a clinical study of multidrug resistance (MDRl) gene therapy. Advanced breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) withMDRl-transduced hematopoietic cells, and then were treated with docetaxel. Two patients have been treated so far, andin vivo enrichment ofMDRl-transduced cells with docetaxel treatment has been seen. Both patients are in complete remission and had no apparent adverse effects from theMDRl gene transfer.

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KW - Retroviral vector

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Gene therapy for breast cancer. — review of clinical gene therapy trials for breast cancer and mdr1 gene therapy trial in cancer institute hospital

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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