Abstract
Gene therapy for advanced breast cancer is anticipated to be a useful therapeutic approach. Strategies in ongoing clinical protocols can be divided into four groups: (1) suppression of oncogenes or transfer of tumor-suppressor genes; (2) enhancement of immunological response; (3) transfer of suicide genes; (4) protection of bone marrow using drug resistance genes. We have started a clinical study of multidrug resistance (MDRl) gene therapy. Advanced breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) withMDRl-transduced hematopoietic cells, and then were treated with docetaxel. Two patients have been treated so far, andin vivo enrichment ofMDRl-transduced cells with docetaxel treatment has been seen. Both patients are in complete remission and had no apparent adverse effects from theMDRl gene transfer.
Original language | English |
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Pages (from-to) | 8-15 |
Number of pages | 8 |
Journal | Breast Cancer |
Volume | 13 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2006 Jan |
Keywords
- Adenoviral vector
- Breast cancer
- Gene therapy
- MDRl
- Retroviral vector
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Pharmacology (medical)