General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment

Emi Nakashima, Leslie Z. Benet

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

A general treatment for mean residence time, clearance, and volume parameters in linear mammillary models which includes the possibility of first-order elimination from compartments other than the central compartment is presented. The interrelationship between noncompartmentally derived parameters and compartmentally derived pharmacokinetic microconstants is described. The concept of exit site dependent and exit site independent parameters is introduced in the development of these treatments. Explications of mean residence time in terms of elimination rate, amount eliminated, and amount in the body are presented together with demonstrations of their utility.

Original languageEnglish
Pages (from-to)475-492
Number of pages18
JournalJournal of Pharmacokinetics and Biopharmaceutics
Volume16
Issue number5
DOIs
Publication statusPublished - 1988 Oct 1

Keywords

  • exit site dependent parameter
  • exit site independent parameter
  • mean residence time
  • mean residence time in central compartment
  • mean residence time in peripheral compartment
  • steady-state volume of distribution, clearance

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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