Generation and characterization of a novel shoulder contracture mouse model

Satoshi Oki, Hideyuki Shirasawa, Masaki Yoda, Noboru Matsumura, Takahide Tohmonda, Kazuki Yuasa, Masaya Nakamura, Morio Matsumoto, Keisuke Horiuchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Frozen shoulder is a relatively common disorder that leads to severe pain and stiffness in the shoulder joint. Although this disorder is self-limiting in nature, the symptoms often persist for years, resulting in severe disability. Recent studies using human specimens and animal models have shown distinct changes in the gene expression patterns in frozen shoulder tissue, indicating that novel therapeutic intervention could be achieved by controlling the genes that are potentially involved in the development of frozen shoulder. To achieve this goal, it is imperative to develop a reliable animal joint contracture model in which gene expression can be manipulated by gene targeting and transgenic technologies. Here, we describe a novel shoulder contracture mouse model. We found that this model mimics the clinical presentation of human frozen shoulder and recapitulates the changes in the gene expression pattern and the histology of frozen shoulder and joint contracture in humans and other larger animal models. The model is highly reproducible, without any major complications. Therefore, the present model may serve as a useful tool for investigating frozen shoulder etiology and for identifying its potential target genes.

Original languageEnglish
Pages (from-to)1732-1738
Number of pages7
JournalJournal of Orthopaedic Research
Volume33
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

Keywords

  • functional analysis
  • gene expression analysis
  • mouse model
  • shoulder contracture

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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