Generation of functional human hepatocytes in vitro: Current status and future prospects

Tomoko Yamaguchi; Juntaro Matsuzaki; Takeshi Katsuda; Yoshimasa Saito; Hidetsugu Saito; Takahiro Ochiya

doi:10.1186/s41232-019-0102-4

Generation of functional human hepatocytes in vitro: Current status and future prospects

Tomoko Yamaguchi, Juntaro Matsuzaki, Takeshi Katsuda, Yoshimasa Saito, Hidetsugu Saito, Takahiro Ochiya

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential alternative approach, functional hepatocytes were recently generated from various cell sources. Analysis of drug metabolism in the human liver is important for drug development. Consequently, cells that metabolize drugs similar to human primary hepatocytes are required. This review discusses the current challenges and future perspectives concerning hepatocytes and hepatic progenitor cells that have been reprogrammed from various cell types, focusing on their functions in transplantation models and their ability to metabolize drugs.

Original language	English
Article number	13
Journal	Inflammation and Regeneration
Volume	39
Issue number	1
DOIs	https://doi.org/10.1186/s41232-019-0102-4
Publication status	Published - 2019 Jul 2

Keywords

Drug metabolism
Hepatocyte
Progenitor cells
Regeneration

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s41232-019-0102-4

Cite this

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title = "Generation of functional human hepatocytes in vitro: Current status and future prospects",

abstract = "Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential alternative approach, functional hepatocytes were recently generated from various cell sources. Analysis of drug metabolism in the human liver is important for drug development. Consequently, cells that metabolize drugs similar to human primary hepatocytes are required. This review discusses the current challenges and future perspectives concerning hepatocytes and hepatic progenitor cells that have been reprogrammed from various cell types, focusing on their functions in transplantation models and their ability to metabolize drugs.",

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T2 - Current status and future prospects

AU - Yamaguchi, Tomoko

AU - Matsuzaki, Juntaro

AU - Katsuda, Takeshi

AU - Saito, Yoshimasa

AU - Saito, Hidetsugu

AU - Ochiya, Takahiro

N1 - Funding Information: This research was funded by a Grant-in-Aid for Scientific Research (C) (17 K09471, to JM) from the Japan Society for the Promotion of Science (JSPS). Publisher Copyright: © 2019 The Author(s).

PY - 2019/7/2

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N2 - Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential alternative approach, functional hepatocytes were recently generated from various cell sources. Analysis of drug metabolism in the human liver is important for drug development. Consequently, cells that metabolize drugs similar to human primary hepatocytes are required. This review discusses the current challenges and future perspectives concerning hepatocytes and hepatic progenitor cells that have been reprogrammed from various cell types, focusing on their functions in transplantation models and their ability to metabolize drugs.

AB - Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential alternative approach, functional hepatocytes were recently generated from various cell sources. Analysis of drug metabolism in the human liver is important for drug development. Consequently, cells that metabolize drugs similar to human primary hepatocytes are required. This review discusses the current challenges and future perspectives concerning hepatocytes and hepatic progenitor cells that have been reprogrammed from various cell types, focusing on their functions in transplantation models and their ability to metabolize drugs.

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KW - Hepatocyte

KW - Progenitor cells

KW - Regeneration

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Generation of functional human hepatocytes in vitro: Current status and future prospects

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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