Generation of neural cells from pluripotent stem cells

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent advances in the establishment and controlled differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have generated new model systems to access the biology of early mammalian, including human, development and to investigate new approaches for regenerative medicine. Among the studies using pluripotent stem cells (PSCs), neural differentiation and its applications have received the most focus, because of the relative ease of neural induction in vitro and the high expectation for transplantation therapeutics to treat neurological disorders. The discovery of iPSCs increased the potential for developing efficient systems for drug discovery and screening, because they enable different types of functional neurons and their precursors to be generated in vitro from patients with genetic disorders. This chapter describes recent advances in protocols for the neural differentiation of PSCs that were designed using findings from basic embryology, and their possible applications.

Original languageEnglish
Title of host publicationNuclear Reprogramming and Stem Cells
PublisherHumana Press Inc.
Pages127-140
Number of pages14
ISBN (Electronic)9781617792250
ISBN (Print)9781617792243
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Stem cells
Preclinical Drug Evaluations
Inborn Genetic Diseases
Regenerative Medicine
Embryology
Human Development
Drug Discovery
Embryonic Stem Cells
Nervous System Diseases
Cell Differentiation
Transplantation
Neurons
Screening
In Vitro Techniques
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shimazaki, T., & Okano, H. (2012). Generation of neural cells from pluripotent stem cells. In Nuclear Reprogramming and Stem Cells (pp. 127-140). Humana Press Inc.. https://doi.org/10.1007/978-1-61779-225-0_11

Generation of neural cells from pluripotent stem cells. / Shimazaki, Takuya; Okano, Hideyuki.

Nuclear Reprogramming and Stem Cells. Humana Press Inc., 2012. p. 127-140.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shimazaki, T & Okano, H 2012, Generation of neural cells from pluripotent stem cells. in Nuclear Reprogramming and Stem Cells. Humana Press Inc., pp. 127-140. https://doi.org/10.1007/978-1-61779-225-0_11
Shimazaki T, Okano H. Generation of neural cells from pluripotent stem cells. In Nuclear Reprogramming and Stem Cells. Humana Press Inc. 2012. p. 127-140 https://doi.org/10.1007/978-1-61779-225-0_11
Shimazaki, Takuya ; Okano, Hideyuki. / Generation of neural cells from pluripotent stem cells. Nuclear Reprogramming and Stem Cells. Humana Press Inc., 2012. pp. 127-140
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