Abstract
We report a case of de novo acute myelomonocytic leukaemia with the t(2;11)(q31;p15) translocation in a Japanese female infant. The NUP98-HOXD13 fusion transcript generated by the translocation was detected in the patient's bone marrow cells by reverse transcription-polymerase chain reaction (RT-PCR). Additionally, ectopic expression of the normal allele of the HOXD13 gene was observed in this patient, suggesting that it might be associated with leukaemogenic development. This case is the third report of t(2;11) leukaemia with NUP98-HOXD13 and the first report showing that NUP98 rearrangements are associated with infant leukaemia, as well as therapy-related acute myelogenous leukaemia or myelodysplastic syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 210-213 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 110 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Acute myelomonocytic leukaemia (M4)
- Infant leukaemia
- NUP98-HOXD13
- Translocation (2;11)(p31;p15)
ASJC Scopus subject areas
- Hematology
Cite this
Generation of the NUP98-HOXD13 fusion transcript by a rare translocation, t(2;11)(q31;p15), in a case of infant leukaemia. / Shimada, Hiroyuki; Arai, Yasuhito; Sekiguchi, Shinichiro; Ishii, Toru; Tanitsu, Shizue; Sasaki, Michiko.
In: British Journal of Haematology, Vol. 110, No. 1, 2000, p. 210-213.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Generation of the NUP98-HOXD13 fusion transcript by a rare translocation, t(2;11)(q31;p15), in a case of infant leukaemia
AU - Shimada, Hiroyuki
AU - Arai, Yasuhito
AU - Sekiguchi, Shinichiro
AU - Ishii, Toru
AU - Tanitsu, Shizue
AU - Sasaki, Michiko
PY - 2000
Y1 - 2000
N2 - We report a case of de novo acute myelomonocytic leukaemia with the t(2;11)(q31;p15) translocation in a Japanese female infant. The NUP98-HOXD13 fusion transcript generated by the translocation was detected in the patient's bone marrow cells by reverse transcription-polymerase chain reaction (RT-PCR). Additionally, ectopic expression of the normal allele of the HOXD13 gene was observed in this patient, suggesting that it might be associated with leukaemogenic development. This case is the third report of t(2;11) leukaemia with NUP98-HOXD13 and the first report showing that NUP98 rearrangements are associated with infant leukaemia, as well as therapy-related acute myelogenous leukaemia or myelodysplastic syndrome.
AB - We report a case of de novo acute myelomonocytic leukaemia with the t(2;11)(q31;p15) translocation in a Japanese female infant. The NUP98-HOXD13 fusion transcript generated by the translocation was detected in the patient's bone marrow cells by reverse transcription-polymerase chain reaction (RT-PCR). Additionally, ectopic expression of the normal allele of the HOXD13 gene was observed in this patient, suggesting that it might be associated with leukaemogenic development. This case is the third report of t(2;11) leukaemia with NUP98-HOXD13 and the first report showing that NUP98 rearrangements are associated with infant leukaemia, as well as therapy-related acute myelogenous leukaemia or myelodysplastic syndrome.
KW - Acute myelomonocytic leukaemia (M4)
KW - Infant leukaemia
KW - NUP98-HOXD13
KW - Translocation (2;11)(p31;p15)
UR - http://www.scopus.com/inward/record.url?scp=0033872049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033872049&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.2000.02172.x
DO - 10.1046/j.1365-2141.2000.02172.x
M3 - Article
VL - 110
SP - 210
EP - 213
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -