Genetic analysis of craniofacial traits in the medaka

Tetsuaki Kimura, Atsuko Shimada, Noriyoshi Sakai, Hiroshi Mitani, Kiyoshi Naruse, Hiroyuki Takeda, Hidetoshi Inoko, Gen Tamiya, Minori Shinya

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Family and twin studies suggest that a substantial genetic component underlies individual differences in craniofacial morphology. In the current study, we quantified 444 craniofacial traits in 100 individuals from two inbred medaka (Oryzias latipes) strains, HNI and Hd-rR. Relative distances between defined landmarks were measured in digital images of the medaka head region. A total of 379 traits differed significantly between the two strains, indicating that many craniofacial traits are controlled by genetic factors. Of these, 89 traits were analyzed via interval mapping of 184 F2 progeny from an intercross between HNI and Hd-rR. We identified quantitative trait loci for 66 craniofacial traits. The highest logarithm of the odds score was 6.2 for linkage group (LG) 9 and 11. Trait L33, which corresponds to the ratio of head length to head height at eye level, mapped to LG9; trait V15, which corresponds to the ratio of snout length to head width measured behind the eyes, mapped to LG11. Our initial results confirm the potential of the medaka as a model system for the genetic analysis of complex traits such as craniofacial morphology.

Original languageEnglish
Pages (from-to)2379-2388
Number of pages10
JournalGenetics
Volume177
Issue number4
DOIs
Publication statusPublished - 2007 Dec
Externally publishedYes

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Oryzias
Head
Twin Studies
Quantitative Trait Loci
Genetic Models
Individuality

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Kimura, T., Shimada, A., Sakai, N., Mitani, H., Naruse, K., Takeda, H., ... Shinya, M. (2007). Genetic analysis of craniofacial traits in the medaka. Genetics, 177(4), 2379-2388. https://doi.org/10.1534/genetics.106.068460

Genetic analysis of craniofacial traits in the medaka. / Kimura, Tetsuaki; Shimada, Atsuko; Sakai, Noriyoshi; Mitani, Hiroshi; Naruse, Kiyoshi; Takeda, Hiroyuki; Inoko, Hidetoshi; Tamiya, Gen; Shinya, Minori.

In: Genetics, Vol. 177, No. 4, 12.2007, p. 2379-2388.

Research output: Contribution to journalArticle

Kimura, T, Shimada, A, Sakai, N, Mitani, H, Naruse, K, Takeda, H, Inoko, H, Tamiya, G & Shinya, M 2007, 'Genetic analysis of craniofacial traits in the medaka', Genetics, vol. 177, no. 4, pp. 2379-2388. https://doi.org/10.1534/genetics.106.068460
Kimura T, Shimada A, Sakai N, Mitani H, Naruse K, Takeda H et al. Genetic analysis of craniofacial traits in the medaka. Genetics. 2007 Dec;177(4):2379-2388. https://doi.org/10.1534/genetics.106.068460
Kimura, Tetsuaki ; Shimada, Atsuko ; Sakai, Noriyoshi ; Mitani, Hiroshi ; Naruse, Kiyoshi ; Takeda, Hiroyuki ; Inoko, Hidetoshi ; Tamiya, Gen ; Shinya, Minori. / Genetic analysis of craniofacial traits in the medaka. In: Genetics. 2007 ; Vol. 177, No. 4. pp. 2379-2388.
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