[Genetic analysis of multidrug-resistant Streptococcus pneumoniae including meropenem resistance that was isolated from elderly residents with pneumonia in nursing-care facilities].

Kazuko Ota, Naoko Chiba, Kentaro Sato, Syoetu Nara, Satoko Kato, Hisao Kanazawa, Shin Ikejima, Yoshihiro Takahashi, Satoshi Iwata, Kimiko Ubukata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

From February to December 20XX, penicillin-resistant Streptococcus pneumoniae (PRSP) showing MICs of 16-32 microg/mL to cefotaxime (CTX) and 4-8 microg/mL to meropenem (MEPM) were isolated from 6 patients hospitalized at the general hospital S (2 cases) and hospital A (4 cases), close to the hospital S. Five elderly patients among these six cases came from nursing care facilities or nursing care-related medical facilities. All elderly persons (mean age: 81.7 years) were diagnosed as having pneumonia at the time of admission and the problematic PRSP was isolated from sputum samples collected on admission. Notably, all of these PRSP isolates simultaneously showed high resistance to macrolide agents mediated by an erm (B) gene and to fluoroquinolone agents via mutations in the gyrA and parC genes. Eventually, they were identified as multidrug-resistant S. pneumoniae (MDRSP) with high resistance to many agents. The capsule type of all strains was serotype 19F and multilocus sequence typing (MLST) revealed that they belonged to clonal complex (CC) 7993, which has not been reported before. It was thus concluded that the MDRSP that had spread within the nursing facilities was transmitted to the general hospitals via the elderly inpatients with pneumonia caused by these agents. Although one case finally had a poor outcome, the pneumococcal infection was not the direct trigger of the event. The current ratio of MDRSP is concluded to be very low. However, general hospitals that accept patients for therapeutic purposes from nursing-care facilities have to share epidemiological information in a timely manner with the nursing homes to prevent nosocomial infections.

Original languageEnglish
Pages (from-to)444-451
Number of pages8
JournalKansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Volume88
Issue number4
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

meropenem
Nursing Care
Streptococcus pneumoniae
Pneumonia
General Hospitals
Penicillins
Multilocus Sequence Typing
Pneumococcal Infections
Cefotaxime
Fluoroquinolones
Macrolides
Cross Infection
Nursing Homes
Sputum
Genes
Capsules
Inpatients
Nursing

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[Genetic analysis of multidrug-resistant Streptococcus pneumoniae including meropenem resistance that was isolated from elderly residents with pneumonia in nursing-care facilities]. / Ota, Kazuko; Chiba, Naoko; Sato, Kentaro; Nara, Syoetu; Kato, Satoko; Kanazawa, Hisao; Ikejima, Shin; Takahashi, Yoshihiro; Iwata, Satoshi; Ubukata, Kimiko.

In: Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 88, No. 4, 2014, p. 444-451.

Research output: Contribution to journalArticle

Ota, Kazuko ; Chiba, Naoko ; Sato, Kentaro ; Nara, Syoetu ; Kato, Satoko ; Kanazawa, Hisao ; Ikejima, Shin ; Takahashi, Yoshihiro ; Iwata, Satoshi ; Ubukata, Kimiko. / [Genetic analysis of multidrug-resistant Streptococcus pneumoniae including meropenem resistance that was isolated from elderly residents with pneumonia in nursing-care facilities]. In: Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 2014 ; Vol. 88, No. 4. pp. 444-451.
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AU - Kato, Satoko

AU - Kanazawa, Hisao

AU - Ikejima, Shin

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