Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins

Y. M. Hur, J. Kaprio, W. G. Iacono, D. I. Boomsma, M. McGue, K. Silventoinen, N. G. Martin, M. Luciano, P. M. Visscher, R. J. Rose, M. He, J. Ando, S. Ooki, K. Nonaka, C. C.H. Lin, H. R. Lajunen, B. K. Cornes, M. Bartels, C. E.M. Van Beijsterveldt, S. S. ChernyK. Mitchell

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians. Design: Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study. Results: The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences. Conclusion: Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups.

Original languageEnglish
Pages (from-to)1455-1467
Number of pages13
JournalInternational Journal of Obesity
Volume32
Issue number10
DOIs
Publication statusPublished - 2008 Oct 1

Keywords

  • BMI
  • Genes
  • Height
  • Population group
  • Twins
  • Weight

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Hur, Y. M., Kaprio, J., Iacono, W. G., Boomsma, D. I., McGue, M., Silventoinen, K., Martin, N. G., Luciano, M., Visscher, P. M., Rose, R. J., He, M., Ando, J., Ooki, S., Nonaka, K., Lin, C. C. H., Lajunen, H. R., Cornes, B. K., Bartels, M., Van Beijsterveldt, C. E. M., ... Mitchell, K. (2008). Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. International Journal of Obesity, 32(10), 1455-1467. https://doi.org/10.1038/ijo.2008.144