Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins

Y. M. Hur, J. Kaprio, W. G. Iacono, D. I. Boomsma, M. McGue, K. Silventoinen, N. G. Martin, M. Luciano, P. M. Visscher, R. J. Rose, M. He, Jyukou Andou, S. Ooki, K. Nonaka, C. C H Lin, H. R. Lajunen, B. K. Cornes, M. Bartels, C. E M Van Beijsterveldt, S. S. Cherny & 1 others K. Mitchell

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians. Design: Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study. Results: The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences. Conclusion: Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups.

Original languageEnglish
Pages (from-to)1455-1467
Number of pages13
JournalInternational Journal of Obesity
Volume32
Issue number10
DOIs
Publication statusPublished - 2008 Oct

Fingerprint

Body Mass Index
Weights and Measures
Body Weights and Measures
Population Groups
Republic of Korea
Twin Studies
Finland
Taiwan
Netherlands
China
Japan
Population

Keywords

  • BMI
  • Genes
  • Height
  • Population group
  • Twins
  • Weight

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. / Hur, Y. M.; Kaprio, J.; Iacono, W. G.; Boomsma, D. I.; McGue, M.; Silventoinen, K.; Martin, N. G.; Luciano, M.; Visscher, P. M.; Rose, R. J.; He, M.; Andou, Jyukou; Ooki, S.; Nonaka, K.; Lin, C. C H; Lajunen, H. R.; Cornes, B. K.; Bartels, M.; Van Beijsterveldt, C. E M; Cherny, S. S.; Mitchell, K.

In: International Journal of Obesity, Vol. 32, No. 10, 10.2008, p. 1455-1467.

Research output: Contribution to journalArticle

Hur, YM, Kaprio, J, Iacono, WG, Boomsma, DI, McGue, M, Silventoinen, K, Martin, NG, Luciano, M, Visscher, PM, Rose, RJ, He, M, Andou, J, Ooki, S, Nonaka, K, Lin, CCH, Lajunen, HR, Cornes, BK, Bartels, M, Van Beijsterveldt, CEM, Cherny, SS & Mitchell, K 2008, 'Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins', International Journal of Obesity, vol. 32, no. 10, pp. 1455-1467. https://doi.org/10.1038/ijo.2008.144
Hur, Y. M. ; Kaprio, J. ; Iacono, W. G. ; Boomsma, D. I. ; McGue, M. ; Silventoinen, K. ; Martin, N. G. ; Luciano, M. ; Visscher, P. M. ; Rose, R. J. ; He, M. ; Andou, Jyukou ; Ooki, S. ; Nonaka, K. ; Lin, C. C H ; Lajunen, H. R. ; Cornes, B. K. ; Bartels, M. ; Van Beijsterveldt, C. E M ; Cherny, S. S. ; Mitchell, K. / Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. In: International Journal of Obesity. 2008 ; Vol. 32, No. 10. pp. 1455-1467.
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AU - Hur, Y. M.

AU - Kaprio, J.

AU - Iacono, W. G.

AU - Boomsma, D. I.

AU - McGue, M.

AU - Silventoinen, K.

AU - Martin, N. G.

AU - Luciano, M.

AU - Visscher, P. M.

AU - Rose, R. J.

AU - He, M.

AU - Andou, Jyukou

AU - Ooki, S.

AU - Nonaka, K.

AU - Lin, C. C H

AU - Lajunen, H. R.

AU - Cornes, B. K.

AU - Bartels, M.

AU - Van Beijsterveldt, C. E M

AU - Cherny, S. S.

AU - Mitchell, K.

PY - 2008/10

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N2 - Objective: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians. Design: Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study. Results: The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences. Conclusion: Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups.

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KW - BMI

KW - Genes

KW - Height

KW - Population group

KW - Twins

KW - Weight

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