Genetic landscape of meningioma

Sayaka Yuzawa, Hiroshi Nishihara, Shinya Tanaka

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed 553 meningiomas for the mutational patterns of the six genes. NF2 aberration was observed in 55 % of meningiomas. Mutations of TRAF7, AKT1, KLF4, PIK3CA, and SMO were identified in 20, 9, 9, 4.5, and 3 % of cases, respectively. Altogether, 80 % of cases harbored at least one of the genetic alterations in these genes. NF2 alterations and mutations of the other genes were mutually exclusive with a few exceptions. Clinicopathologically, tumors with mutations in TRAF7/AKT1 and SMO shared specific features: they were located in the anterior fossa, median middle fossa, or anterior calvarium, and most of them were meningothelial or transitional meningiomas. TRAF7/KLF4 type meningiomas showed different characteristics in that they occurred in the lateral middle fossa and median posterior fossa as well as anterior fossa and median middle fossa, and contained a secretory meningioma component. We also discuss the mutational hotspots of these genes and other genetic/cytogenetic alterations contributing to tumorigenesis or progression of meningiomas.

Original languageEnglish
Pages (from-to)237-247
Number of pages11
JournalBrain tumor pathology
Volume33
Issue number4
DOIs
Publication statusPublished - 2016 Oct 1
Externally publishedYes

Fingerprint

Meningioma
Mutation
Genes
Secretory Component
Arachnoid
Monosomy
Meninges
Skull
Cytogenetics
Neoplasms
Carcinogenesis

Keywords

  • Genetics
  • Meningioma
  • Next-generation sequencers

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Genetic landscape of meningioma. / Yuzawa, Sayaka; Nishihara, Hiroshi; Tanaka, Shinya.

In: Brain tumor pathology, Vol. 33, No. 4, 01.10.2016, p. 237-247.

Research output: Contribution to journalArticle

Yuzawa, Sayaka ; Nishihara, Hiroshi ; Tanaka, Shinya. / Genetic landscape of meningioma. In: Brain tumor pathology. 2016 ; Vol. 33, No. 4. pp. 237-247.
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