Genetic linkage of the sarco(endo)plasmic reticulum Ca2+-dependent ATPase II gene to intracellular Ca2+ concentration in the spontaneously hypertensive rat

Yoichi Ohno, Koichi Matsuo, Hiromichi Suzuki, Hisao Tanase, Tadao Serikawa, Toshiya Takano, Takao Saruta

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A cosegregation analysis of sarco(endo)plasmic reticulum Ca2+-dependent ATPase (SERCA) II genotype, systolic blood pressure and platelet intracellular Ca2+ concentration was performed to dissect polygenic hypertensive traits in spontaneously hypertensive rats. Backcross analysis between spontaneously hypertensive hypertensive rats and normotensive Donryu rats demonstrated the existence of an inferred single major gene locus (ht). Thrombin-stimulated intraplatelet Ca2+ concentration was significantly higher in the SERCA II homozygotes than in the heterozygotes. The SERCA II genotype did not cosegregate with the blood pressure level. The SERCA II gene was assigned to rat chromosome 12. These results suggest that the SERCA II gene on rat chromosome 12 contributes to increased thrombin-stimulated intraplatelet Ca2+ concentration and that the SERCA II gene is not identical to ht.

Original languageEnglish
Pages (from-to)789-793
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 1996 Oct 23


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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