TY - JOUR
T1 - Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea
AU - Tanaka, Misuzu
AU - Kobayashi, Daisuke
AU - Murakami, Yuko
AU - Ozaki, Norio
AU - Suzuki, Tatsuyo
AU - Iwata, Nakao
AU - Haraguchi, Koichi
AU - Ieiri, Ichiro
AU - Kinukawa, Naoko
AU - Hosoi, Masako
AU - Ohtani, Hisakazu
AU - Sawada, Yasufumi
AU - Mine, Kazunori
PY - 2008/3
Y1 - 2008/3
N2 - Selective serotonin reuptake inhibitor (SSRI)-induced nausea can be severe enough to lead to early treatment discontinuation. However, it is currently not possible to predict the occurrence of nausea before the initiation of SSRI treatment. In this study, we investigated the effect of genetic polymorphisms in the 5-hydroxytryptamine type 2A, 3A, and 3B (5-HT3B) receptors, 5-HT transporter, and CYP2D6 genes on the incidence of paroxetine-induced nausea. A consecutive series of 72 Japanese patients with depressive or anxiety disorders were treated with paroxetine. Paroxetine-induced nausea was assessed by a pharmacist and was observed in 29.2% of the patients. A significant (nominal p=0.00286) association was found between the incidence of nausea and the -100_-102AAG insertion/deletion polymorphism of the 5-HT3B receptor gene. No significant associations were observed between the other genetic polymorphisms and the incidence of nausea. The -100_-102AAG deletion variant of the 5-HT3B receptor gene may a.ect paroxetine-induced nausea.
AB - Selective serotonin reuptake inhibitor (SSRI)-induced nausea can be severe enough to lead to early treatment discontinuation. However, it is currently not possible to predict the occurrence of nausea before the initiation of SSRI treatment. In this study, we investigated the effect of genetic polymorphisms in the 5-hydroxytryptamine type 2A, 3A, and 3B (5-HT3B) receptors, 5-HT transporter, and CYP2D6 genes on the incidence of paroxetine-induced nausea. A consecutive series of 72 Japanese patients with depressive or anxiety disorders were treated with paroxetine. Paroxetine-induced nausea was assessed by a pharmacist and was observed in 29.2% of the patients. A significant (nominal p=0.00286) association was found between the incidence of nausea and the -100_-102AAG insertion/deletion polymorphism of the 5-HT3B receptor gene. No significant associations were observed between the other genetic polymorphisms and the incidence of nausea. The -100_-102AAG deletion variant of the 5-HT3B receptor gene may a.ect paroxetine-induced nausea.
KW - 5-hydroxytryptamine type 3B receptor
KW - Genetic polymorphism
KW - Nausea
KW - Paroxetine
KW - Selective serotonin reuptake inhibitor
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U2 - 10.1017/S1461145707007985
DO - 10.1017/S1461145707007985
M3 - Article
C2 - 17697394
AN - SCOPUS:38949107641
SN - 1461-1457
VL - 11
SP - 261
EP - 267
JO - International Journal of Neuropsychopharmacology
JF - International Journal of Neuropsychopharmacology
IS - 2
ER -
