Genitourinary toxicity after permanent iodine-125 seed implantation: The nationwide Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS)

J-POPS Study Group

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2 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to evaluate acute and late genitourinary (GU) toxicity and to elucidate factors associated with GU toxicity in patients with prostate cancer treated with permanent seed implantation (PI) enrolled in a nationwide prospective cohort study in Japan. Methods and Materials: Of 2,354 patients enrolled in this study, GU toxicity was evaluated in 2,339 patients at 3, 12, 24, and 36 months after PI. To elucidate independent factors predictive of acute and late Common Terminology Criteria for Adverse Events Grade 2 or higher (Grade ≥2) GU toxicity, multivariate logistic regression analyses were carried out. Regarding acute urinary retention (AUR), the incidence rate and the recovery rate for AUR were estimated using the Kaplan–Meier curve. Results: Approximately 53% of the patients treated with PI alone and 42% of those treated with combination therapy with PI therapy and external beam radiation therapy showed urinary frequency/urgency at 3 months. The multivariate analysis revealed that age, prostate volume, pretreatment international prostate symptom score, drinking status, and PI were independent predictors of acute GU toxicity Grade ≥2. Of all patients, 53 (2.3%) suffered from AUR, and 49 (92.5%) recovered from AUR with a median time of 4.3 months during the followup period. Conclusions: The results of GU toxicity in Japanese patients who underwent low-dose-rate brachytherapy were acceptable and comparable to those previously reported in U.S. patients. The patients treated with PI alone showed a significantly higher incidence rate of GU toxicity than did those undergoing combination therapy with PI and external beam radiation therapy in the acute phase.

Original languageEnglish
JournalBrachytherapy
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Iodine
Prostatic Neoplasms
Seeds
Outcome Assessment (Health Care)
Urinary Retention
Prostate
Radiotherapy
Incidence
Brachytherapy
Terminology
Drinking
Japan
Cohort Studies
Therapeutics
Multivariate Analysis
Logistic Models
Regression Analysis
Prospective Studies

Keywords

  • Acute urinary retention
  • Genitourinary toxicity
  • Low-dose-rate brachytherapy
  • Permanent seed implantation
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

@article{5536f607244945d38ae3f60b64c9df34,
title = "Genitourinary toxicity after permanent iodine-125 seed implantation: The nationwide Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS)",
abstract = "Purpose: The purpose of this study was to evaluate acute and late genitourinary (GU) toxicity and to elucidate factors associated with GU toxicity in patients with prostate cancer treated with permanent seed implantation (PI) enrolled in a nationwide prospective cohort study in Japan. Methods and Materials: Of 2,354 patients enrolled in this study, GU toxicity was evaluated in 2,339 patients at 3, 12, 24, and 36 months after PI. To elucidate independent factors predictive of acute and late Common Terminology Criteria for Adverse Events Grade 2 or higher (Grade ≥2) GU toxicity, multivariate logistic regression analyses were carried out. Regarding acute urinary retention (AUR), the incidence rate and the recovery rate for AUR were estimated using the Kaplan–Meier curve. Results: Approximately 53{\%} of the patients treated with PI alone and 42{\%} of those treated with combination therapy with PI therapy and external beam radiation therapy showed urinary frequency/urgency at 3 months. The multivariate analysis revealed that age, prostate volume, pretreatment international prostate symptom score, drinking status, and PI were independent predictors of acute GU toxicity Grade ≥2. Of all patients, 53 (2.3{\%}) suffered from AUR, and 49 (92.5{\%}) recovered from AUR with a median time of 4.3 months during the followup period. Conclusions: The results of GU toxicity in Japanese patients who underwent low-dose-rate brachytherapy were acceptable and comparable to those previously reported in U.S. patients. The patients treated with PI alone showed a significantly higher incidence rate of GU toxicity than did those undergoing combination therapy with PI and external beam radiation therapy in the acute phase.",
keywords = "Acute urinary retention, Genitourinary toxicity, Low-dose-rate brachytherapy, Permanent seed implantation, Prostate cancer",
author = "{J-POPS Study Group} and Nobumichi Tanaka and Atsunori Yorozu and Takashi Kikuchi and Satoshi Higashide and Shinsuke Kojima and Toshio Ohashi and Norihisa Katayama and Katsumasa Nakamura and Shiro Saito and Takushi Dokiya and Masanori Fukushima",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.brachy.2019.03.007",
language = "English",
journal = "Brachytherapy",
issn = "1538-4721",
publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Genitourinary toxicity after permanent iodine-125 seed implantation

T2 - The nationwide Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS)

AU - J-POPS Study Group

AU - Tanaka, Nobumichi

AU - Yorozu, Atsunori

AU - Kikuchi, Takashi

AU - Higashide, Satoshi

AU - Kojima, Shinsuke

AU - Ohashi, Toshio

AU - Katayama, Norihisa

AU - Nakamura, Katsumasa

AU - Saito, Shiro

AU - Dokiya, Takushi

AU - Fukushima, Masanori

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: The purpose of this study was to evaluate acute and late genitourinary (GU) toxicity and to elucidate factors associated with GU toxicity in patients with prostate cancer treated with permanent seed implantation (PI) enrolled in a nationwide prospective cohort study in Japan. Methods and Materials: Of 2,354 patients enrolled in this study, GU toxicity was evaluated in 2,339 patients at 3, 12, 24, and 36 months after PI. To elucidate independent factors predictive of acute and late Common Terminology Criteria for Adverse Events Grade 2 or higher (Grade ≥2) GU toxicity, multivariate logistic regression analyses were carried out. Regarding acute urinary retention (AUR), the incidence rate and the recovery rate for AUR were estimated using the Kaplan–Meier curve. Results: Approximately 53% of the patients treated with PI alone and 42% of those treated with combination therapy with PI therapy and external beam radiation therapy showed urinary frequency/urgency at 3 months. The multivariate analysis revealed that age, prostate volume, pretreatment international prostate symptom score, drinking status, and PI were independent predictors of acute GU toxicity Grade ≥2. Of all patients, 53 (2.3%) suffered from AUR, and 49 (92.5%) recovered from AUR with a median time of 4.3 months during the followup period. Conclusions: The results of GU toxicity in Japanese patients who underwent low-dose-rate brachytherapy were acceptable and comparable to those previously reported in U.S. patients. The patients treated with PI alone showed a significantly higher incidence rate of GU toxicity than did those undergoing combination therapy with PI and external beam radiation therapy in the acute phase.

AB - Purpose: The purpose of this study was to evaluate acute and late genitourinary (GU) toxicity and to elucidate factors associated with GU toxicity in patients with prostate cancer treated with permanent seed implantation (PI) enrolled in a nationwide prospective cohort study in Japan. Methods and Materials: Of 2,354 patients enrolled in this study, GU toxicity was evaluated in 2,339 patients at 3, 12, 24, and 36 months after PI. To elucidate independent factors predictive of acute and late Common Terminology Criteria for Adverse Events Grade 2 or higher (Grade ≥2) GU toxicity, multivariate logistic regression analyses were carried out. Regarding acute urinary retention (AUR), the incidence rate and the recovery rate for AUR were estimated using the Kaplan–Meier curve. Results: Approximately 53% of the patients treated with PI alone and 42% of those treated with combination therapy with PI therapy and external beam radiation therapy showed urinary frequency/urgency at 3 months. The multivariate analysis revealed that age, prostate volume, pretreatment international prostate symptom score, drinking status, and PI were independent predictors of acute GU toxicity Grade ≥2. Of all patients, 53 (2.3%) suffered from AUR, and 49 (92.5%) recovered from AUR with a median time of 4.3 months during the followup period. Conclusions: The results of GU toxicity in Japanese patients who underwent low-dose-rate brachytherapy were acceptable and comparable to those previously reported in U.S. patients. The patients treated with PI alone showed a significantly higher incidence rate of GU toxicity than did those undergoing combination therapy with PI and external beam radiation therapy in the acute phase.

KW - Acute urinary retention

KW - Genitourinary toxicity

KW - Low-dose-rate brachytherapy

KW - Permanent seed implantation

KW - Prostate cancer

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U2 - 10.1016/j.brachy.2019.03.007

DO - 10.1016/j.brachy.2019.03.007

M3 - Article

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AN - SCOPUS:85065081128

JO - Brachytherapy

JF - Brachytherapy

SN - 1538-4721

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