Genome evolution to penicillin resistance in serotype 3 streptococcus pneumoniae by capsular switching

Naoko Chiba, Somay Y. Murayama, Miyuki Morozumi, Satoshi Iwata, Kimiko Ubukata

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3 Citations (Scopus)


Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease (n 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.

Original languageEnglish
Article numbere00478-17
JournalAntimicrobial Agents and Chemotherapy
Issue number9
Publication statusPublished - 2017 Sep 1



  • Capsular switching
  • Serotype 3
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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