Genome evolution to penicillin resistance in serotype 3 streptococcus pneumoniae by capsular switching

Naoko Chiba; Somay Y. Murayama; Miyuki Morozumi; Satoshi Iwata; Kimiko Ubukata

doi:10.1128/AAC.00478-17

Genome evolution to penicillin resistance in serotype 3 streptococcus pneumoniae by capsular switching

Naoko Chiba, Somay Y. Murayama, Miyuki Morozumi, Satoshi Iwata, Kimiko Ubukata

Department of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease (n 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.

Original language	English
Article number	e00478-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00478-17
Publication status	Published - 2017 Sept

Keywords

Capsular switching
GPRSP
Serotype 3
Streptococcus pneumoniae

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00478-17

Cite this

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title = "Genome evolution to penicillin resistance in serotype 3 streptococcus pneumoniae by capsular switching",

abstract = "Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease (n 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.",

keywords = "Capsular switching, GPRSP, Serotype 3, Streptococcus pneumoniae",

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AU - Chiba, Naoko

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AU - Morozumi, Miyuki

AU - Iwata, Satoshi

AU - Ubukata, Kimiko

N1 - Funding Information: This work was supported by two grants, one from JSPS KAKENHI (26870568) and the other from the Japanese Ministry of Health, Labor and Welfare (Research on Emerging and Re-emerging Infectious Diseases H22-013) (to K.U.). Publisher Copyright: Copyright © 2017 American Society for Microbiology. All Rights Reserved.

PY - 2017/9

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N2 - Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease (n 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.

AB - Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease (n 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.

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KW - Serotype 3

KW - Streptococcus pneumoniae

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Genome evolution to penicillin resistance in serotype 3 streptococcus pneumoniae by capsular switching

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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