Genome-wide association study for adolescent idiopathic scoliosis

Japan Scoliosis Clinical Research Group

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Adolescent idiopathic scoliosis(AIS)is a polygenic disease. Genome-wide association studies(GWASs)have been performed for a lot of polygenic diseases. For AIS, we conducted GWAS and identified the first AIS locus near LBX1. After the discovery, we have extended our study by increasing the numbers of subjects and SNPs. In total, our Japanese GWAS has identified four susceptibility genes. GWASs for AIS have also been performed in the USA and China, which identified one and three susceptibility genes, respectively. Here we review GWASs in Japan and abroad and functional analysis to clarify the pathomechanism of AIS.

Original languageEnglish
Pages (from-to)553-560
Number of pages8
JournalClinical calcium
Volume26
Issue number4
Publication statusPublished - 2016 Apr 1

Fingerprint

Genome-Wide Association Study
Scoliosis
Genes
Single Nucleotide Polymorphism
China
Japan

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Japan Scoliosis Clinical Research Group (2016). Genome-wide association study for adolescent idiopathic scoliosis. Clinical calcium, 26(4), 553-560.

Genome-wide association study for adolescent idiopathic scoliosis. / Japan Scoliosis Clinical Research Group.

In: Clinical calcium, Vol. 26, No. 4, 01.04.2016, p. 553-560.

Research output: Contribution to journalReview article

Japan Scoliosis Clinical Research Group 2016, 'Genome-wide association study for adolescent idiopathic scoliosis', Clinical calcium, vol. 26, no. 4, pp. 553-560.
Japan Scoliosis Clinical Research Group. Genome-wide association study for adolescent idiopathic scoliosis. Clinical calcium. 2016 Apr 1;26(4):553-560.
Japan Scoliosis Clinical Research Group. / Genome-wide association study for adolescent idiopathic scoliosis. In: Clinical calcium. 2016 ; Vol. 26, No. 4. pp. 553-560.
@article{7fcfaec40ccc4f64b86d70db8394ae37,
title = "Genome-wide association study for adolescent idiopathic scoliosis",
abstract = "Adolescent idiopathic scoliosis(AIS)is a polygenic disease. Genome-wide association studies(GWASs)have been performed for a lot of polygenic diseases. For AIS, we conducted GWAS and identified the first AIS locus near LBX1. After the discovery, we have extended our study by increasing the numbers of subjects and SNPs. In total, our Japanese GWAS has identified four susceptibility genes. GWASs for AIS have also been performed in the USA and China, which identified one and three susceptibility genes, respectively. Here we review GWASs in Japan and abroad and functional analysis to clarify the pathomechanism of AIS.",
author = "{Japan Scoliosis Clinical Research Group} and Yoji Ogura and Ikuyo Kou and Japan Scoliosis and Morio Matsumoto and Morio Matsumoto and Koota Watanabe",
year = "2016",
month = "4",
day = "1",
language = "English",
volume = "26",
pages = "553--560",
journal = "Clinical calcium",
issn = "0917-5857",
publisher = "Iyaku (Medicine & Drug) Journal Co",
number = "4",

}

TY - JOUR

T1 - Genome-wide association study for adolescent idiopathic scoliosis

AU - Japan Scoliosis Clinical Research Group

AU - Ogura, Yoji

AU - Kou, Ikuyo

AU - Scoliosis, Japan

AU - Matsumoto, Morio

AU - Matsumoto, Morio

AU - Watanabe, Koota

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Adolescent idiopathic scoliosis(AIS)is a polygenic disease. Genome-wide association studies(GWASs)have been performed for a lot of polygenic diseases. For AIS, we conducted GWAS and identified the first AIS locus near LBX1. After the discovery, we have extended our study by increasing the numbers of subjects and SNPs. In total, our Japanese GWAS has identified four susceptibility genes. GWASs for AIS have also been performed in the USA and China, which identified one and three susceptibility genes, respectively. Here we review GWASs in Japan and abroad and functional analysis to clarify the pathomechanism of AIS.

AB - Adolescent idiopathic scoliosis(AIS)is a polygenic disease. Genome-wide association studies(GWASs)have been performed for a lot of polygenic diseases. For AIS, we conducted GWAS and identified the first AIS locus near LBX1. After the discovery, we have extended our study by increasing the numbers of subjects and SNPs. In total, our Japanese GWAS has identified four susceptibility genes. GWASs for AIS have also been performed in the USA and China, which identified one and three susceptibility genes, respectively. Here we review GWASs in Japan and abroad and functional analysis to clarify the pathomechanism of AIS.

UR - http://www.scopus.com/inward/record.url?scp=84984815965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984815965&partnerID=8YFLogxK

M3 - Review article

C2 - 27013625

AN - SCOPUS:84984815965

VL - 26

SP - 553

EP - 560

JO - Clinical calcium

JF - Clinical calcium

SN - 0917-5857

IS - 4

ER -