Genome-wide association study for white coat effect in Japanese middle-aged to elderly people

The HOMED-BP study

Soshiro Ogata, Kei Kamide, Kei Asayama, Yasuharu Tabara, Takahisa Kawaguchi, Michihiro Satoh, Tomohiro Katsuya, Ken Sugimoto, Takuo Hirose, Ryusuke Inoue, Azusa Hara, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Fumihiko Matsuda, Jan A. Staessen, Takayoshi Ohkubo, Hiromi Rakugi, Yutaka Imai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: White coat effect (WCE), the blood pressure (BP) difference between clinical and non-clinical settings, can lead to clinical problems such as misdiagnosis of hypertension. Etiology of WCE has been still unclear, especially from genetic aspects. The present article investigated association between genome-wide single nucleotide polymorphisms (SNPs) and WCE in patients with essential hypertension. Methods: The present cross-sectional analyses were based on 295 Japanese essential hypertensive outpatients aged ≧40 years enrolled in randomized control study, Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study, who were not taking antihypertensive medications before the randomization. Home and clinic BP were measured. WCE was defined by subtracting home BP from clinic BP. Genotyping was conducted with 500K DNA microarray chips. Association between genome-wide SNPs and WCE were analyzed. For replication (p < 10 –4 ), we analyzed participants from Ohasama study who took no antihypertension medications and whose SNPs were collected. Results: Genome-wide SNPs were not significantly associated with WCE of systolic and diastolic BP after corrections of multiple comparisons (p < 2 × 10 –7 ). We found suggestive SNPs associated with WCE of systolic and diastolic BP (p < 10 –4 ). However, the consistent results were not obtained in the replication study. Conclusion: The present article showed no significant association between genome-wide SNPs and WCE. Since there were several suggestive SNPs associated with WCE, the present study warrants a further study with bigger sample size for investigating the genetic influence on WCE.

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalClinical and Experimental Hypertension
Volume40
Issue number4
DOIs
Publication statusPublished - 2018 May 19
Externally publishedYes

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Genome-Wide Association Study
Blood Pressure
Single Nucleotide Polymorphism
Genome
Oligonucleotide Array Sequence Analysis
Hypertension
Random Allocation
Diagnostic Errors
Sample Size
Antihypertensive Agents
Outpatients
Cross-Sectional Studies
Equipment and Supplies

Keywords

  • epidemiology
  • genome-wide association study
  • Japan
  • White coat effect
  • white coat hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Genome-wide association study for white coat effect in Japanese middle-aged to elderly people : The HOMED-BP study. / Ogata, Soshiro; Kamide, Kei; Asayama, Kei; Tabara, Yasuharu; Kawaguchi, Takahisa; Satoh, Michihiro; Katsuya, Tomohiro; Sugimoto, Ken; Hirose, Takuo; Inoue, Ryusuke; Hara, Azusa; Obara, Taku; Kikuya, Masahiro; Metoki, Hirohito; Matsuda, Fumihiko; Staessen, Jan A.; Ohkubo, Takayoshi; Rakugi, Hiromi; Imai, Yutaka.

In: Clinical and Experimental Hypertension, Vol. 40, No. 4, 19.05.2018, p. 363-369.

Research output: Contribution to journalArticle

Ogata, S, Kamide, K, Asayama, K, Tabara, Y, Kawaguchi, T, Satoh, M, Katsuya, T, Sugimoto, K, Hirose, T, Inoue, R, Hara, A, Obara, T, Kikuya, M, Metoki, H, Matsuda, F, Staessen, JA, Ohkubo, T, Rakugi, H & Imai, Y 2018, 'Genome-wide association study for white coat effect in Japanese middle-aged to elderly people: The HOMED-BP study', Clinical and Experimental Hypertension, vol. 40, no. 4, pp. 363-369. https://doi.org/10.1080/10641963.2017.1384481
Ogata, Soshiro ; Kamide, Kei ; Asayama, Kei ; Tabara, Yasuharu ; Kawaguchi, Takahisa ; Satoh, Michihiro ; Katsuya, Tomohiro ; Sugimoto, Ken ; Hirose, Takuo ; Inoue, Ryusuke ; Hara, Azusa ; Obara, Taku ; Kikuya, Masahiro ; Metoki, Hirohito ; Matsuda, Fumihiko ; Staessen, Jan A. ; Ohkubo, Takayoshi ; Rakugi, Hiromi ; Imai, Yutaka. / Genome-wide association study for white coat effect in Japanese middle-aged to elderly people : The HOMED-BP study. In: Clinical and Experimental Hypertension. 2018 ; Vol. 40, No. 4. pp. 363-369.
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abstract = "Background: White coat effect (WCE), the blood pressure (BP) difference between clinical and non-clinical settings, can lead to clinical problems such as misdiagnosis of hypertension. Etiology of WCE has been still unclear, especially from genetic aspects. The present article investigated association between genome-wide single nucleotide polymorphisms (SNPs) and WCE in patients with essential hypertension. Methods: The present cross-sectional analyses were based on 295 Japanese essential hypertensive outpatients aged ≧40 years enrolled in randomized control study, Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study, who were not taking antihypertensive medications before the randomization. Home and clinic BP were measured. WCE was defined by subtracting home BP from clinic BP. Genotyping was conducted with 500K DNA microarray chips. Association between genome-wide SNPs and WCE were analyzed. For replication (p < 10 –4 ), we analyzed participants from Ohasama study who took no antihypertension medications and whose SNPs were collected. Results: Genome-wide SNPs were not significantly associated with WCE of systolic and diastolic BP after corrections of multiple comparisons (p < 2 × 10 –7 ). We found suggestive SNPs associated with WCE of systolic and diastolic BP (p < 10 –4 ). However, the consistent results were not obtained in the replication study. Conclusion: The present article showed no significant association between genome-wide SNPs and WCE. Since there were several suggestive SNPs associated with WCE, the present study warrants a further study with bigger sample size for investigating the genetic influence on WCE.",
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T1 - Genome-wide association study for white coat effect in Japanese middle-aged to elderly people

T2 - The HOMED-BP study

AU - Ogata, Soshiro

AU - Kamide, Kei

AU - Asayama, Kei

AU - Tabara, Yasuharu

AU - Kawaguchi, Takahisa

AU - Satoh, Michihiro

AU - Katsuya, Tomohiro

AU - Sugimoto, Ken

AU - Hirose, Takuo

AU - Inoue, Ryusuke

AU - Hara, Azusa

AU - Obara, Taku

AU - Kikuya, Masahiro

AU - Metoki, Hirohito

AU - Matsuda, Fumihiko

AU - Staessen, Jan A.

AU - Ohkubo, Takayoshi

AU - Rakugi, Hiromi

AU - Imai, Yutaka

PY - 2018/5/19

Y1 - 2018/5/19

N2 - Background: White coat effect (WCE), the blood pressure (BP) difference between clinical and non-clinical settings, can lead to clinical problems such as misdiagnosis of hypertension. Etiology of WCE has been still unclear, especially from genetic aspects. The present article investigated association between genome-wide single nucleotide polymorphisms (SNPs) and WCE in patients with essential hypertension. Methods: The present cross-sectional analyses were based on 295 Japanese essential hypertensive outpatients aged ≧40 years enrolled in randomized control study, Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study, who were not taking antihypertensive medications before the randomization. Home and clinic BP were measured. WCE was defined by subtracting home BP from clinic BP. Genotyping was conducted with 500K DNA microarray chips. Association between genome-wide SNPs and WCE were analyzed. For replication (p < 10 –4 ), we analyzed participants from Ohasama study who took no antihypertension medications and whose SNPs were collected. Results: Genome-wide SNPs were not significantly associated with WCE of systolic and diastolic BP after corrections of multiple comparisons (p < 2 × 10 –7 ). We found suggestive SNPs associated with WCE of systolic and diastolic BP (p < 10 –4 ). However, the consistent results were not obtained in the replication study. Conclusion: The present article showed no significant association between genome-wide SNPs and WCE. Since there were several suggestive SNPs associated with WCE, the present study warrants a further study with bigger sample size for investigating the genetic influence on WCE.

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KW - genome-wide association study

KW - Japan

KW - White coat effect

KW - white coat hypertension

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