Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations

Emiko Noguchi, Hiromi Sakamoto, Tomomitsu Hirota, Kaori Ochiai, Yoshimasa Imoto, Masafumi Sakashita, Fumitake Kurosaka, Akira Akasawa, Shigemi Yoshihara, Noriko Kanno, Yumi Yamada, Naoki Shimojo, Yoichi Kohno, Yoichi Suzuki, Mi Jin Kang, Ji Won Kwon, Soo Jong Hong, Ken Inoue, Yu Ichi Goto, Fumio Yamashita & 14 others Takashi Asada, Hiroshi Hirose, Ikuo Saito, Shigeharu Fujieda, Nobuyuki Hizawa, Toru Sakamoto, Hironori Masuko, Yusuke Nakamura, Ichiro Nomura, Mayumi Tamari, Tadao Arinami, Teruhiko Yoshida, Hirohisa Saito, Kenji Matsumoto

Research output: Contribution to journalArticle

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Abstract

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10 -8) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P combined = 2.3×10 -10, odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10 -10, OR = 1.52, and DPB1*0901: P = 2.0×10 -7, OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.

Original languageEnglish
Article numbere1002170
JournalPLoS Genetics
Volume7
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Fingerprint

HLA-DP Antigens
Genome-Wide Association Study
asthma
Asthma
genome
Pediatrics
gene
odds ratio
Population
Genes
Odds Ratio
genes
single nucleotide polymorphism
Single Nucleotide Polymorphism
polymorphism
Linkage Disequilibrium
linkage disequilibrium
disequilibrium
phenotype
allele

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Noguchi, E., Sakamoto, H., Hirota, T., Ochiai, K., Imoto, Y., Sakashita, M., ... Matsumoto, K. (2011). Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genetics, 7(7), [e1002170]. https://doi.org/10.1371/journal.pgen.1002170

Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. / Noguchi, Emiko; Sakamoto, Hiromi; Hirota, Tomomitsu; Ochiai, Kaori; Imoto, Yoshimasa; Sakashita, Masafumi; Kurosaka, Fumitake; Akasawa, Akira; Yoshihara, Shigemi; Kanno, Noriko; Yamada, Yumi; Shimojo, Naoki; Kohno, Yoichi; Suzuki, Yoichi; Kang, Mi Jin; Kwon, Ji Won; Hong, Soo Jong; Inoue, Ken; Goto, Yu Ichi; Yamashita, Fumio; Asada, Takashi; Hirose, Hiroshi; Saito, Ikuo; Fujieda, Shigeharu; Hizawa, Nobuyuki; Sakamoto, Toru; Masuko, Hironori; Nakamura, Yusuke; Nomura, Ichiro; Tamari, Mayumi; Arinami, Tadao; Yoshida, Teruhiko; Saito, Hirohisa; Matsumoto, Kenji.

In: PLoS Genetics, Vol. 7, No. 7, e1002170, 07.2011.

Research output: Contribution to journalArticle

Noguchi, E, Sakamoto, H, Hirota, T, Ochiai, K, Imoto, Y, Sakashita, M, Kurosaka, F, Akasawa, A, Yoshihara, S, Kanno, N, Yamada, Y, Shimojo, N, Kohno, Y, Suzuki, Y, Kang, MJ, Kwon, JW, Hong, SJ, Inoue, K, Goto, YI, Yamashita, F, Asada, T, Hirose, H, Saito, I, Fujieda, S, Hizawa, N, Sakamoto, T, Masuko, H, Nakamura, Y, Nomura, I, Tamari, M, Arinami, T, Yoshida, T, Saito, H & Matsumoto, K 2011, 'Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations', PLoS Genetics, vol. 7, no. 7, e1002170. https://doi.org/10.1371/journal.pgen.1002170
Noguchi, Emiko ; Sakamoto, Hiromi ; Hirota, Tomomitsu ; Ochiai, Kaori ; Imoto, Yoshimasa ; Sakashita, Masafumi ; Kurosaka, Fumitake ; Akasawa, Akira ; Yoshihara, Shigemi ; Kanno, Noriko ; Yamada, Yumi ; Shimojo, Naoki ; Kohno, Yoichi ; Suzuki, Yoichi ; Kang, Mi Jin ; Kwon, Ji Won ; Hong, Soo Jong ; Inoue, Ken ; Goto, Yu Ichi ; Yamashita, Fumio ; Asada, Takashi ; Hirose, Hiroshi ; Saito, Ikuo ; Fujieda, Shigeharu ; Hizawa, Nobuyuki ; Sakamoto, Toru ; Masuko, Hironori ; Nakamura, Yusuke ; Nomura, Ichiro ; Tamari, Mayumi ; Arinami, Tadao ; Yoshida, Teruhiko ; Saito, Hirohisa ; Matsumoto, Kenji. / Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. In: PLoS Genetics. 2011 ; Vol. 7, No. 7.
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AU - Shimojo, Naoki

AU - Kohno, Yoichi

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AU - Kang, Mi Jin

AU - Kwon, Ji Won

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AU - Inoue, Ken

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AU - Nomura, Ichiro

AU - Tamari, Mayumi

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