Abstract
Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value <5×10-7) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30×10-7, 3.30×10-7, and 4.41×10-7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
| Original language | English |
|---|---|
| Article number | e11824 |
| Journal | PLoS One |
| Volume | 5 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2010 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Genome-wide association study of pancreatic cancer in Japanese population. / Low, Siew Kee; Kuchiba, Aya; Zembutsu, Hitoshi; Saito, Akira; Takahashi, Atsushi; Kubo, Michiaki; Daigo, Yataro; Kamatani, Naoyuki; Chiku, Suenori; Totsuka, Hirohiko; Ohnami, Sumiko; Hirose, Hiroshi; Shimada, Kazuaki; Okusaka, Takuji; Yoshida, Teruhiko; Nakamura, Yusuke; Sakamoto, Hiromi.
In: PLoS One, Vol. 5, No. 7, e11824, 2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genome-wide association study of pancreatic cancer in Japanese population
AU - Low, Siew Kee
AU - Kuchiba, Aya
AU - Zembutsu, Hitoshi
AU - Saito, Akira
AU - Takahashi, Atsushi
AU - Kubo, Michiaki
AU - Daigo, Yataro
AU - Kamatani, Naoyuki
AU - Chiku, Suenori
AU - Totsuka, Hirohiko
AU - Ohnami, Sumiko
AU - Hirose, Hiroshi
AU - Shimada, Kazuaki
AU - Okusaka, Takuji
AU - Yoshida, Teruhiko
AU - Nakamura, Yusuke
AU - Sakamoto, Hiromi
PY - 2010
Y1 - 2010
N2 - Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value <5×10-7) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30×10-7, 3.30×10-7, and 4.41×10-7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
AB - Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value <5×10-7) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30×10-7, 3.30×10-7, and 4.41×10-7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
UR - http://www.scopus.com/inward/record.url?scp=77955606616&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955606616&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0011824
DO - 10.1371/journal.pone.0011824
M3 - Article
C2 - 20686608
AN - SCOPUS:77955606616
VL - 5
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 7
M1 - e11824
ER -