Genome-wide association study of pancreatic cancer in Japanese population

Siew Kee Low, Aya Kuchiba, Hitoshi Zembutsu, Akira Saito, Atsushi Takahashi, Michiaki Kubo, Yataro Daigo, Naoyuki Kamatani, Suenori Chiku, Hirohiko Totsuka, Sumiko Ohnami, Hiroshi Hirose, Kazuaki Shimada, Takuji Okusaka, Teruhiko Yoshida, Yusuke Nakamura, Hiromi Sakamoto

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Abstract

Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value <5×10-7) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30×10-7, 3.30×10-7, and 4.41×10-7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.

Original languageEnglish
Article numbere11824
JournalPLoS One
Volume5
Issue number7
DOIs
Publication statusPublished - 2010

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Low, S. K., Kuchiba, A., Zembutsu, H., Saito, A., Takahashi, A., Kubo, M., Daigo, Y., Kamatani, N., Chiku, S., Totsuka, H., Ohnami, S., Hirose, H., Shimada, K., Okusaka, T., Yoshida, T., Nakamura, Y., & Sakamoto, H. (2010). Genome-wide association study of pancreatic cancer in Japanese population. PLoS One, 5(7), [e11824]. https://doi.org/10.1371/journal.pone.0011824