Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21

Kentaro Nagamine, Jun Kudo, Shinsei Minoshima, Kazuhiko Kawasaki, Shuichi Asakawa, Fumiaki Ito, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats. Genomic sequencing revealed that the human PWP2 gene consists of 21 exons spanning approximately 24 kb and locates just between the two genes EHOC-1 and KNP-I and distal to a NotI site of LJ104 (D21S1460) on chromosome 21q22.3. Analysis of the 5'-flanking DNA sequence revealed that the upstream region of the PWP2 gene is associated with a CpG island containing the NotI site of LJ104. Since PWP2 is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including nucleotide sequence and genomic organization of the PWP2 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.

Original languageEnglish
Pages (from-to)528-531
Number of pages4
JournalGenomics
Volume42
Issue number3
DOIs
Publication statusPublished - 1997 Jun 15

Fingerprint

Chromosomes, Human, Pair 21
Genes
Inborn Genetic Diseases
CpG Islands
5' Flanking Region
Aspartic Acid
Tryptophan
Exons
Chromosomes
Mutation

ASJC Scopus subject areas

  • Genetics

Cite this

Nagamine, K., Kudo, J., Minoshima, S., Kawasaki, K., Asakawa, S., Ito, F., & Shimizu, N. (1997). Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21. Genomics, 42(3), 528-531. https://doi.org/10.1006/geno.1997.4761

Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21. / Nagamine, Kentaro; Kudo, Jun; Minoshima, Shinsei; Kawasaki, Kazuhiko; Asakawa, Shuichi; Ito, Fumiaki; Shimizu, Nobuyoshi.

In: Genomics, Vol. 42, No. 3, 15.06.1997, p. 528-531.

Research output: Contribution to journalArticle

Nagamine, K, Kudo, J, Minoshima, S, Kawasaki, K, Asakawa, S, Ito, F & Shimizu, N 1997, 'Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21', Genomics, vol. 42, no. 3, pp. 528-531. https://doi.org/10.1006/geno.1997.4761
Nagamine K, Kudo J, Minoshima S, Kawasaki K, Asakawa S, Ito F et al. Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21. Genomics. 1997 Jun 15;42(3):528-531. https://doi.org/10.1006/geno.1997.4761
Nagamine, Kentaro ; Kudo, Jun ; Minoshima, Shinsei ; Kawasaki, Kazuhiko ; Asakawa, Shuichi ; Ito, Fumiaki ; Shimizu, Nobuyoshi. / Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21. In: Genomics. 1997 ; Vol. 42, No. 3. pp. 528-531.
@article{963758d6af7f49cab62811b325b73d1b,
title = "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21",
abstract = "The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats. Genomic sequencing revealed that the human PWP2 gene consists of 21 exons spanning approximately 24 kb and locates just between the two genes EHOC-1 and KNP-I and distal to a NotI site of LJ104 (D21S1460) on chromosome 21q22.3. Analysis of the 5'-flanking DNA sequence revealed that the upstream region of the PWP2 gene is associated with a CpG island containing the NotI site of LJ104. Since PWP2 is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including nucleotide sequence and genomic organization of the PWP2 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.",
author = "Kentaro Nagamine and Jun Kudo and Shinsei Minoshima and Kazuhiko Kawasaki and Shuichi Asakawa and Fumiaki Ito and Nobuyoshi Shimizu",
year = "1997",
month = "6",
day = "15",
doi = "10.1006/geno.1997.4761",
language = "English",
volume = "42",
pages = "528--531",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21

AU - Nagamine, Kentaro

AU - Kudo, Jun

AU - Minoshima, Shinsei

AU - Kawasaki, Kazuhiko

AU - Asakawa, Shuichi

AU - Ito, Fumiaki

AU - Shimizu, Nobuyoshi

PY - 1997/6/15

Y1 - 1997/6/15

N2 - The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats. Genomic sequencing revealed that the human PWP2 gene consists of 21 exons spanning approximately 24 kb and locates just between the two genes EHOC-1 and KNP-I and distal to a NotI site of LJ104 (D21S1460) on chromosome 21q22.3. Analysis of the 5'-flanking DNA sequence revealed that the upstream region of the PWP2 gene is associated with a CpG island containing the NotI site of LJ104. Since PWP2 is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including nucleotide sequence and genomic organization of the PWP2 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.

AB - The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats. Genomic sequencing revealed that the human PWP2 gene consists of 21 exons spanning approximately 24 kb and locates just between the two genes EHOC-1 and KNP-I and distal to a NotI site of LJ104 (D21S1460) on chromosome 21q22.3. Analysis of the 5'-flanking DNA sequence revealed that the upstream region of the PWP2 gene is associated with a CpG island containing the NotI site of LJ104. Since PWP2 is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including nucleotide sequence and genomic organization of the PWP2 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.

UR - http://www.scopus.com/inward/record.url?scp=0031570671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031570671&partnerID=8YFLogxK

U2 - 10.1006/geno.1997.4761

DO - 10.1006/geno.1997.4761

M3 - Article

VL - 42

SP - 528

EP - 531

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 3

ER -