Genotoxicity studies of heavy metals

Lead, bismuth, indium, silver and antimony

Keiko Asakura, Hiroshi Satoh, Momoko Chiba, Masahide Okamoto, Koji Serizawa, Makiko Nakano, Kazuyuki Omae

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objectives: Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible substitutes for lead in solder. Methods: Bacterial reverse mutation tests and chromosomal aberration tests in cultured mammalian cells were performed according to standard procedures. Results: Antimony showed genotoxicity in both tests, and bismuth also showed positive results in the chromosomal aberration test. In contrast, lead, indium, and silver were considered to be inactive by the criteria of the present study. Conclusions: Although further studies are needed because of the difficulty of genotoxicity evaluation using an in vitro system, sufficient precautions should be made when antimony and bismuth are used.

Original languageEnglish
Pages (from-to)498-512
Number of pages15
JournalJournal of Occupational Health
Volume51
Issue number6
DOIs
Publication statusPublished - 2009 Nov

Fingerprint

Antimony
Indium
Heavy Metals
Silver
Bismuth
Aberrations
Chromosome Aberrations
Soldering alloys
Toxicity
Cultured Cells
Industry
Cells
Mutation
bismuth lead
Lead

Keywords

  • Bacterial reverse mutation test
  • Chromosomal aberration test in cultured mammalian cells
  • Genotoxicity
  • Heavy metals

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Genotoxicity studies of heavy metals : Lead, bismuth, indium, silver and antimony. / Asakura, Keiko; Satoh, Hiroshi; Chiba, Momoko; Okamoto, Masahide; Serizawa, Koji; Nakano, Makiko; Omae, Kazuyuki.

In: Journal of Occupational Health, Vol. 51, No. 6, 11.2009, p. 498-512.

Research output: Contribution to journalArticle

Asakura, K, Satoh, H, Chiba, M, Okamoto, M, Serizawa, K, Nakano, M & Omae, K 2009, 'Genotoxicity studies of heavy metals: Lead, bismuth, indium, silver and antimony', Journal of Occupational Health, vol. 51, no. 6, pp. 498-512. https://doi.org/10.1539/joh.L9080
Asakura, Keiko ; Satoh, Hiroshi ; Chiba, Momoko ; Okamoto, Masahide ; Serizawa, Koji ; Nakano, Makiko ; Omae, Kazuyuki. / Genotoxicity studies of heavy metals : Lead, bismuth, indium, silver and antimony. In: Journal of Occupational Health. 2009 ; Vol. 51, No. 6. pp. 498-512.
@article{e7f5d663adcc4e0eaa5fd12b312d0b0f,
title = "Genotoxicity studies of heavy metals: Lead, bismuth, indium, silver and antimony",
abstract = "Objectives: Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible substitutes for lead in solder. Methods: Bacterial reverse mutation tests and chromosomal aberration tests in cultured mammalian cells were performed according to standard procedures. Results: Antimony showed genotoxicity in both tests, and bismuth also showed positive results in the chromosomal aberration test. In contrast, lead, indium, and silver were considered to be inactive by the criteria of the present study. Conclusions: Although further studies are needed because of the difficulty of genotoxicity evaluation using an in vitro system, sufficient precautions should be made when antimony and bismuth are used.",
keywords = "Bacterial reverse mutation test, Chromosomal aberration test in cultured mammalian cells, Genotoxicity, Heavy metals",
author = "Keiko Asakura and Hiroshi Satoh and Momoko Chiba and Masahide Okamoto and Koji Serizawa and Makiko Nakano and Kazuyuki Omae",
year = "2009",
month = "11",
doi = "10.1539/joh.L9080",
language = "English",
volume = "51",
pages = "498--512",
journal = "Journal of Occupational Health",
issn = "1341-9145",
publisher = "Japan Society for Occupational Health",
number = "6",

}

TY - JOUR

T1 - Genotoxicity studies of heavy metals

T2 - Lead, bismuth, indium, silver and antimony

AU - Asakura, Keiko

AU - Satoh, Hiroshi

AU - Chiba, Momoko

AU - Okamoto, Masahide

AU - Serizawa, Koji

AU - Nakano, Makiko

AU - Omae, Kazuyuki

PY - 2009/11

Y1 - 2009/11

N2 - Objectives: Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible substitutes for lead in solder. Methods: Bacterial reverse mutation tests and chromosomal aberration tests in cultured mammalian cells were performed according to standard procedures. Results: Antimony showed genotoxicity in both tests, and bismuth also showed positive results in the chromosomal aberration test. In contrast, lead, indium, and silver were considered to be inactive by the criteria of the present study. Conclusions: Although further studies are needed because of the difficulty of genotoxicity evaluation using an in vitro system, sufficient precautions should be made when antimony and bismuth are used.

AB - Objectives: Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible substitutes for lead in solder. Methods: Bacterial reverse mutation tests and chromosomal aberration tests in cultured mammalian cells were performed according to standard procedures. Results: Antimony showed genotoxicity in both tests, and bismuth also showed positive results in the chromosomal aberration test. In contrast, lead, indium, and silver were considered to be inactive by the criteria of the present study. Conclusions: Although further studies are needed because of the difficulty of genotoxicity evaluation using an in vitro system, sufficient precautions should be made when antimony and bismuth are used.

KW - Bacterial reverse mutation test

KW - Chromosomal aberration test in cultured mammalian cells

KW - Genotoxicity

KW - Heavy metals

UR - http://www.scopus.com/inward/record.url?scp=74549172858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74549172858&partnerID=8YFLogxK

U2 - 10.1539/joh.L9080

DO - 10.1539/joh.L9080

M3 - Article

VL - 51

SP - 498

EP - 512

JO - Journal of Occupational Health

JF - Journal of Occupational Health

SN - 1341-9145

IS - 6

ER -