Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics

Michinaga Matsumoto, Hisao Takahashi, Katsuya Maruyama, Susumu Higuchi, Sachio Matsushita, Taro Muramatsu, Keiji Okuyama, Akira Yokoyama, Masayuki Nakano, Hiromasa Ishii

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38 Citations (Scopus)

Abstract

Genetic predisposition to alcoholism and alcoholic liver disease has been reported. However, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. To determine it, we examined genotype patterns of aldehyde dehydrogenase (ALDH2), alcohol dehydrogenase (ADH2 and ADH3), and cytochrome P-4502E1 (CYP2E1) in alcoholic pancreatitis patients. In 296 alcoholic patients, 52 cases showed findings of chronic pancreatitis by ultrasonography and x-ray computed tomography and/or had a history of pancreatitis (P+). The remaining 244 patients had neither abnormal findings of the image examinations nor a history of pancreatitis (P-). As for the ADH2 genotype, distribution of 21/21, 21/22, and 22/22 was 22, 37, and 42% in P+ patients, whereas 34, 35, and 30% in P- patients, respectively. The frequency of ADH22/22 genotype was significantly higher in P+ patients, compared with that in P- patients. There were no significant differences in the distribution of ADH3, ALDH2, and CYP2E1 genotypes between P+ and P- patients. In 14 alcoholic patients who showed low contents of fecal chymotrypsin, which suggests dysfunction of pancreatic exocrine, the rate of ADH22/22 genotype also tended to be higher (50%) than in 74 controls who showed normal contents of the fecal chymotrypsin (28%). No differences were observed in genotypes of ADH3, ALDH2, and CYP2E1. Moreover, the frequency of ADH22/22 genotype was significantly higher in autopsy cases with interlobular fibrosis in the pancreas, which suggests alcoholic pancreatic damage, than in cases with only intralobular pancreatic fibrosis. These data suggest that the risk of alcoholic pancreatitis seems to be associated with the presence of ADH22/22 genotype.

Original languageEnglish
Pages (from-to)289A-292A
JournalAlcoholism: Clinical and Experimental Research
Volume20
Issue number9 SUPPL.
DOIs
Publication statusPublished - 1996 Dec 1
Externally publishedYes

Keywords

  • ADH
  • ALDH
  • Alcoholic Pancreatitis
  • Cytochrome P-4502E1
  • Genotype

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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    Matsumoto, M., Takahashi, H., Maruyama, K., Higuchi, S., Matsushita, S., Muramatsu, T., Okuyama, K., Yokoyama, A., Nakano, M., & Ishii, H. (1996). Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. Alcoholism: Clinical and Experimental Research, 20(9 SUPPL.), 289A-292A. https://doi.org/10.1111/j.1530-0277.1996.tb01159.x