Geometric changes in ventriculoaortic complex after transcatheter aortic valve replacement and its association with post-procedural prosthesis-patient mismatch: An intraprocedural 3D-TEE study

Hiroto Utsunomiya, Hirotsugu Mihara, Yuji Itabashi, Sayuki Kobayashi, Robert J. Siegel, Tarun Chakravarty, Hasan Jilaihawi, Raj R. Makkar, Takahiro Shiota

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) leads to increased mortality. However, its peri-procedural determinants remain unknown. We investigated geometric changes in aortic annulus (AoA) and left ventricular outflow tract (LVOT) during TAVR by three-dimensional transoesophageal echocardiography (3D-TEE) and its association with post-procedural PPM. Methods and results A total of 131 patients with severe aortic stenosis underwent intraprocedural 3D-TEE during balloon-expandable TAVR. The severity of PPM was graded using the indexed effective orifice area calculated by Doppler echocardiography at discharge, with moderate defined as ≥0.65 and ≤0.85 cm2/m2 and severe defined as ,0.65 cm2/m2. 3D planimetered AoA area decreased after TAVR (P , 0.001), whereas the LVOT increased (P = 0.004). The eccentricity of both AoA and LVOT decreased after TAVR (both, P , 0.001). At discharge, the incidence of overall and severe PPM was 44 and 12%, respectively. Patients with PPM had a larger body surface area, smaller aortic valve area, and less frequent balloon dilation (all P , 0.05). Patients with PPM had a lower post-TAVR AoA area/pre-TAVR AoA area (91+8 vs. 95+7%, P = 0.001) than those without PPM. The post-TAVR AoA area/pre-TAVR AoA area was independently associated with overall PPM (odds ratio, 1.80; 95% CI, 1.06-3.05; P = 0.031) and severe PPM (odds ratio, 2.50; 95% CI, 1.05-5.36; P = 0.04). Additionally, a cut-off value of this ratio .86.3% had a sensitivity of 84% and a specificity of 44% for the prevention of severe PPM. Conclusion 3D-TEE can evaluate geometric changes in AoA and LVOT during balloon-expandable TAVR and predicts postprocedural PPM.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalEuropean Heart Journal Cardiovascular Imaging
Volume18
Issue number1
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Echocardiography
  • Patient mismatch
  • Prosthesis
  • Three-dimensional transoesophageal
  • Transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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