Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs

Hironori Ushijima, Ken Ichiiro Tanaka, Miho Takeda, Takashi Katsu, Shinji Mima, Tohru Mizushima

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Direct gastric mucosal cell damage mediated by nonsteroidal anti-inflammatory drugs (NSAIDs) is involved in the formation of NSAID-induced gastric lesions. We recently suggested that this direct cytotoxicity of NSAIDs is caused by their membrane-permeabilization activity. Geranylgeranylacetone (GGA), a clinically used antiulcer drug, can protect gastric mucosa against lesion formation mediated by NSAIDs. However, the mechanism by which this occurs is not fully understood. In this study, we show that GGA acts to stabilize membranes against NSAIDs. GGA suppressed NSAID-induced permeabilization of calcein-loaded liposomes and NSAID-induced stimulation of K+-efflux across the cytoplasmic membrane in cells. GGA was effective even when coadministered with NSAIDs and was also able to restore membrane fluidity that had been compromised by NSAIDs. This mechanism seems to play an important role in the antiulcer activity of GGA.

Original languageEnglish
Pages (from-to)1156-1161
Number of pages6
JournalMolecular Pharmacology
Volume68
Issue number4
DOIs
Publication statusPublished - 2005 Oct

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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