Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities

Satoko Zenitani, Satoshi Tashiro, Kazutoshi Shindo, Koji Nagai, Kenichi Suzuki, Masaya Imoto

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalJournal of Antibiotics
Volume56
Issue number7
DOIs
Publication statusPublished - 2003 Aug 1

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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