TRAIL selectively kills cancer cells without harming most normal cells. However, TRAIL resistance is a major problem for its therapeutic use. Developing a strategy to overcome resistance is crucial for the successful use of TRAIL as an antitumor agent. In our screening program of natural products that can abrogate TRAIL resistance, four germacranolides (1-4) were isolated from the aerial parts of Enhydra fluctuans. All compounds exhibited potent TRAILresistance overcoming activity against TRAIL-resistant human gastric adenocarcinoma (AGS) cells.
- Enhydra fluctuans
- TRAIL-resistance overcoming activity
ASJC Scopus subject areas
- Plant Science
- Drug Discovery
- Complementary and alternative medicine