Giant Cell Fibroblastoma: A Case Report and lmmunohistochemical Comparison with Ten Cases of Dermatofibrosarcoma Protuberans

Yae Kanai, Makio Mukai, Hitoshi Sugiura, Yoichi Tanaka, Kiyoshi Mukai, Etsushi Ukiyama, Jotaro Yokoyama, Hisami Iri, Yasuhiro Hosoda

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Abstract

A 7 year old boy with giant cell fibroblastoma (GCF) of the skin and subcutaneous tissue of the right chest wall is described. To date, the histogenesis of GCF has not been clarified. The reason for the diversity of immunohistochemical data among various authors may be because the specimens studied were from only part of the lesion, or reduction of antigenicity through the preparation process. However, our findings based on studies of many specimens from various parts of the tumor for accurate immunohistochemical evaluation suggest that GCF may be a myofibro histiocytic tumor. Recently, the suggestion that GCF is a juvenile form of dermatofibrosarcoma protuberans (DFSP) has been reported. In addition to the present case, we performed immunohistochemical examination of 10cases of definitely diagnosed DFSP for comparison. The immunohistochemical characteristics of these two neoplasms were concordant. However, from clinical and morphological viewpoints, it seems premature to recognize GCF as a juvenile form of DFSP. Acta Pathol Jpn 41: 552–560, 1991.

Original languageEnglish
Pages (from-to)552-560
Number of pages9
JournalPathology International
Volume41
Issue number7
DOIs
Publication statusPublished - 1991

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Dermatofibrosarcoma
Neoplasms
Subcutaneous Tissue
Thoracic Wall
Skin

Keywords

  • Dermatofibrosarcoma protuberans
  • Giant cell fibroblastoma
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Giant Cell Fibroblastoma : A Case Report and lmmunohistochemical Comparison with Ten Cases of Dermatofibrosarcoma Protuberans. / Kanai, Yae; Mukai, Makio; Sugiura, Hitoshi; Tanaka, Yoichi; Mukai, Kiyoshi; Ukiyama, Etsushi; Yokoyama, Jotaro; Iri, Hisami; Hosoda, Yasuhiro.

In: Pathology International, Vol. 41, No. 7, 1991, p. 552-560.

Research output: Contribution to journalArticle

Kanai, Yae ; Mukai, Makio ; Sugiura, Hitoshi ; Tanaka, Yoichi ; Mukai, Kiyoshi ; Ukiyama, Etsushi ; Yokoyama, Jotaro ; Iri, Hisami ; Hosoda, Yasuhiro. / Giant Cell Fibroblastoma : A Case Report and lmmunohistochemical Comparison with Ten Cases of Dermatofibrosarcoma Protuberans. In: Pathology International. 1991 ; Vol. 41, No. 7. pp. 552-560.
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