TY - JOUR
T1 - Giant Cell Fibroblastoma
T2 - A Case Report and lmmunohistochemical Comparison with Ten Cases of Dermatofibrosarcoma Protuberans
AU - Kanai, Yae
AU - Mukai, Makio
AU - Sugiura, Hitoshi
AU - Tanaka, Yoichi
AU - Mukai, Kiyoshi
AU - Ukiyama, Etsushi
AU - Yokoyama, Jotaro
AU - Iri, Hisami
AU - Hosoda, Yasuhiro
PY - 1991/7
Y1 - 1991/7
N2 - A 7 year old boy with giant cell fibroblastoma (GCF) of the skin and subcutaneous tissue of the right chest wall is described. To date, the histogenesis of GCF has not been clarified. The reason for the diversity of immunohistochemical data among various authors may be because the specimens studied were from only part of the lesion, or reduction of antigenicity through the preparation process. However, our findings based on studies of many specimens from various parts of the tumor for accurate immunohistochemical evaluation suggest that GCF may be a myofibro histiocytic tumor. Recently, the suggestion that GCF is a juvenile form of dermatofibrosarcoma protuberans (DFSP) has been reported. In addition to the present case, we performed immunohistochemical examination of 10cases of definitely diagnosed DFSP for comparison. The immunohistochemical characteristics of these two neoplasms were concordant. However, from clinical and morphological viewpoints, it seems premature to recognize GCF as a juvenile form of DFSP. Acta Pathol Jpn 41: 552–560, 1991.
AB - A 7 year old boy with giant cell fibroblastoma (GCF) of the skin and subcutaneous tissue of the right chest wall is described. To date, the histogenesis of GCF has not been clarified. The reason for the diversity of immunohistochemical data among various authors may be because the specimens studied were from only part of the lesion, or reduction of antigenicity through the preparation process. However, our findings based on studies of many specimens from various parts of the tumor for accurate immunohistochemical evaluation suggest that GCF may be a myofibro histiocytic tumor. Recently, the suggestion that GCF is a juvenile form of dermatofibrosarcoma protuberans (DFSP) has been reported. In addition to the present case, we performed immunohistochemical examination of 10cases of definitely diagnosed DFSP for comparison. The immunohistochemical characteristics of these two neoplasms were concordant. However, from clinical and morphological viewpoints, it seems premature to recognize GCF as a juvenile form of DFSP. Acta Pathol Jpn 41: 552–560, 1991.
KW - Dermatofibrosarcoma protuberans
KW - Giant cell fibroblastoma
KW - Immunohistochemistry
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U2 - 10.1111/j.1440-1827.1991.tb02520.x
DO - 10.1111/j.1440-1827.1991.tb02520.x
M3 - Article
C2 - 1755320
AN - SCOPUS:0025886938
SN - 1320-5463
VL - 41
SP - 552
EP - 560
JO - Acta Pathologica Japonica
JF - Acta Pathologica Japonica
IS - 7
ER -