Gingipains as candidate antigens for Porphyromonas gingivalis vaccine

Taneaki Nakagawa, Atsushi Saito, Yasuo Hosaka, Kazuyuki Ishihara

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobe, is involved in the pathogenesis of periodontal disease, and is found frequently in the subgingival flora in patients with periodontitis. This organism possesses a variety of virulence factors including lipopolysaccharide, capsular material, fimbriae and proteases (enzymes). Among the P. gingivalis antigens, enzymes such as Arginine-specific gingipains (RgpA, RgpB) and lysine-specific gingipain (Kgp) have been studied for their ability to induce biologically significant antibodies. This review summarizes recent information on the gingipains and their possible application in the development of an anti-P. gingivalis vaccine.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalKeio Journal of Medicine
Volume52
Issue number3
Publication statusPublished - 2003 Sep

Fingerprint

Porphyromonas gingivalis
Vaccines
Antigens
Periodontitis
Periodontal Diseases
Virulence Factors
Enzymes
Lipopolysaccharides
Arginine
Peptide Hydrolases
Antibodies
Porphyromonas gingivalis argingipain

Keywords

  • Gingipain
  • Periodontal disease
  • Porphyromonas gingivalis
  • Vaccine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gingipains as candidate antigens for Porphyromonas gingivalis vaccine. / Nakagawa, Taneaki; Saito, Atsushi; Hosaka, Yasuo; Ishihara, Kazuyuki.

In: Keio Journal of Medicine, Vol. 52, No. 3, 09.2003, p. 158-162.

Research output: Contribution to journalArticle

Nakagawa, T, Saito, A, Hosaka, Y & Ishihara, K 2003, 'Gingipains as candidate antigens for Porphyromonas gingivalis vaccine', Keio Journal of Medicine, vol. 52, no. 3, pp. 158-162.
Nakagawa, Taneaki ; Saito, Atsushi ; Hosaka, Yasuo ; Ishihara, Kazuyuki. / Gingipains as candidate antigens for Porphyromonas gingivalis vaccine. In: Keio Journal of Medicine. 2003 ; Vol. 52, No. 3. pp. 158-162.
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