Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia

M. Iino, K. Goto, Wataru Kakegawa, H. Okado, M. Sudo, S. Ishiuchi, A. Miwa, Y. Takayasu, I. Saito, K. Tsuzuki, S. Ozawa

Research output: Contribution to journalArticle

295 Citations (Scopus)

Abstract

Glial cells express a variety of neurotransmitter receptors. Notably, Bergmann glial cells in the cerebellum have Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) assembled without the GluR2 subunit. To elucidate the role of these Ca2+-permeable AMPARs, we converted them into Ca2+-impermeable receptors by adenoviral-mediated delivery of the GluR2 gene. This conversion retracted the glial processes ensheathing synapses on Purkinje cell dendritic spines and retarded the removal of synaptically released glutamate. Furthermore, it caused multiple innervation of Purkinje cells by the climbing fibers. Thus, the glial Ca2+-permeable AMPARs are indispensable for proper structural and functional relations between Bergmann glia and glutamatergic synapses.

Original languageEnglish
Pages (from-to)926-929
Number of pages4
JournalScience
Volume292
Issue number5518
DOIs
Publication statusPublished - 2001 May 4
Externally publishedYes

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AMPA Receptors
Neuroglia
Synapses
Glutamate Receptors
Purkinje Cells
Dendritic Spines
Neurotransmitter Receptor
Cerebellum
Glutamic Acid
Acids
Genes

ASJC Scopus subject areas

  • General

Cite this

Iino, M., Goto, K., Kakegawa, W., Okado, H., Sudo, M., Ishiuchi, S., ... Ozawa, S. (2001). Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia. Science, 292(5518), 926-929. https://doi.org/10.1126/science.1058827

Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia. / Iino, M.; Goto, K.; Kakegawa, Wataru; Okado, H.; Sudo, M.; Ishiuchi, S.; Miwa, A.; Takayasu, Y.; Saito, I.; Tsuzuki, K.; Ozawa, S.

In: Science, Vol. 292, No. 5518, 04.05.2001, p. 926-929.

Research output: Contribution to journalArticle

Iino, M, Goto, K, Kakegawa, W, Okado, H, Sudo, M, Ishiuchi, S, Miwa, A, Takayasu, Y, Saito, I, Tsuzuki, K & Ozawa, S 2001, 'Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia', Science, vol. 292, no. 5518, pp. 926-929. https://doi.org/10.1126/science.1058827
Iino, M. ; Goto, K. ; Kakegawa, Wataru ; Okado, H. ; Sudo, M. ; Ishiuchi, S. ; Miwa, A. ; Takayasu, Y. ; Saito, I. ; Tsuzuki, K. ; Ozawa, S. / Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia. In: Science. 2001 ; Vol. 292, No. 5518. pp. 926-929.
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