Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency

and The International Limbal Stem Cell Deficiency Working Group

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE: Despite extensive knowledge gained over the last 3 decades regarding limbal stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of agreement on the diagnostic criteria, staging, and classification system among treating physicians and research scientists working on this field. There is therefore an unmet need to obtain global consensus on the definition, classification, diagnosis, and staging of LSCD. METHODS: A Limbal Stem Cell Working Group was first established by The Cornea Society in 2012. The Working Group was divided into subcommittees. Four face-to-face meetings, frequent email discussions, and teleconferences were conducted since then to obtain agreement on a strategic plan and methodology from all participants after a comprehensive literature search, and final agreement was reached on the definition, classification, diagnosis, and staging of LSCD. A writing group was formed to draft the current manuscript, which has been extensively revised to reflect the consensus of the Working Group. RESULTS: A consensus was reached on the definition, classification, diagnosis, and staging of LSCD. The clinical presentation and diagnostic criteria of LSCD were clarified, and a staging system of LSCD based on clinical presentation was established. CONCLUSIONS: This global consensus provides a comprehensive framework for the definition, classification, diagnosis, and staging of LSCD. The newly established criteria will aid in the correct diagnosis and formulation of an appropriate treatment for different stages of LSCD, which will facilitate a better understanding of the condition and help with clinical management, research, and clinical trials in this area.

Original languageEnglish
Pages (from-to)364-375
Number of pages12
JournalCornea
Volume38
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

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Stem Cells
Deficiency Diseases
Telecommunications
Manuscripts
Research
Cornea
Clinical Trials
Physicians

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency. / and The International Limbal Stem Cell Deficiency Working Group.

In: Cornea, Vol. 38, No. 3, 01.03.2019, p. 364-375.

Research output: Contribution to journalArticle

and The International Limbal Stem Cell Deficiency Working Group 2019, 'Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency', Cornea, vol. 38, no. 3, pp. 364-375. https://doi.org/10.1097/ICO.0000000000001820
and The International Limbal Stem Cell Deficiency Working Group. / Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency. In: Cornea. 2019 ; Vol. 38, No. 3. pp. 364-375.
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AU - Dana, Reza

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AB - PURPOSE: Despite extensive knowledge gained over the last 3 decades regarding limbal stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of agreement on the diagnostic criteria, staging, and classification system among treating physicians and research scientists working on this field. There is therefore an unmet need to obtain global consensus on the definition, classification, diagnosis, and staging of LSCD. METHODS: A Limbal Stem Cell Working Group was first established by The Cornea Society in 2012. The Working Group was divided into subcommittees. Four face-to-face meetings, frequent email discussions, and teleconferences were conducted since then to obtain agreement on a strategic plan and methodology from all participants after a comprehensive literature search, and final agreement was reached on the definition, classification, diagnosis, and staging of LSCD. A writing group was formed to draft the current manuscript, which has been extensively revised to reflect the consensus of the Working Group. RESULTS: A consensus was reached on the definition, classification, diagnosis, and staging of LSCD. The clinical presentation and diagnostic criteria of LSCD were clarified, and a staging system of LSCD based on clinical presentation was established. CONCLUSIONS: This global consensus provides a comprehensive framework for the definition, classification, diagnosis, and staging of LSCD. The newly established criteria will aid in the correct diagnosis and formulation of an appropriate treatment for different stages of LSCD, which will facilitate a better understanding of the condition and help with clinical management, research, and clinical trials in this area.

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