Global consensus on definition, classification, diagnosis, and staging of limbal stem cell deficiency

Sophie X. Deng, Vincent Borderie, Clara C. Chan, Reza Dana, Francisco C. Figueiredo, José A.P. Gomes, Graziella Pellegrini, Shigeto Shimmura, Friedrich E. Kruse

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Purpose: Despite extensive knowledge gained over the last 3 decades regarding limbal stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of agreement on the diagnostic criteria, staging, and classification system among treating physicians and research scientists working on this field. There is therefore an unmet need to obtain global consensus on the definition, classification, diagnosis, and staging of LSCD. Methods: A Limbal Stem Cell Working Group was first established by The Cornea Society in 2012. The Working Group was divided into subcommittees. Four face-to-face meetings, frequent email discussions, and teleconferences were conducted since then to obtain agreement on a strategic plan and methodology from all participants after a comprehensive literature search, and final agreement was reached on the definition, classification, diagnosis, and staging of LSCD. A writing group was formed to draft the current manuscript, which has been extensively revised to reflect the consensus of the Working Group. Results: A consensus was reached on the definition, classification, diagnosis, and staging of LSCD. The clinical presentation and diagnostic criteria of LSCD were clarified, and a staging system of LSCD based on clinical presentation was established. Conclusions: This global consensus provides a comprehensive framework for the definition, classification, diagnosis, and staging of LSCD. The newly established criteria will aid in the correct diagnosis and formulation of an appropriate treatment for different stages of LSCD, which will facilitate a better understanding of the condition and help with clinical management, research, and clinical trials in this area.

Original languageEnglish
Pages (from-to)364-375
Number of pages12
JournalCornea
Volume38
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

Keywords

  • anterior segment optical coherence tomography
  • classification
  • conjunctiva
  • cornea
  • definition
  • diagnosis
  • impression cytology
  • in vivo confocal microscopy
  • limbal stem cell deficiency
  • limbal stem cells
  • markers

ASJC Scopus subject areas

  • Ophthalmology

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