Glomerulomegaly in lupus nephritis

A prognostic marker for renal outcomes

Research output: Contribution to journalArticle

Abstract

Aim: Glomerulomegaly refers to the abnormal enlargement of glomeruli and is associated with an increased risk of progressive chronic kidney disease (CKD). However, it has rarely been investigated in lupus nephritis (LN). We therefore assessed glomerulomegaly as a prognostic factor for renal pathology. Method: Patients with class III or IV LN were retrospectively recruited and divided into two groups according to complete renal response (CR) at 3 years after the initiation of induction therapy. Baseline clinical and renal pathological findings were compared to identify prognostic factors, and patients were followed for up to 10 years to assess long-term renal outcomes. Results: Nineteen patients with and 19 without CR on 3-year follow-up were analyzed. Long-term disease duration and high levels of proteinuria were frequently observed in patients without CR (P = 0.03 and P = 0.01, respectively) at baseline compared to those with CR. On renal pathological analysis, a significantly higher proportion of patients without CR had enlarged glomeruli than those with CR (P = 0.03) in analysis of segmentally or minimally affected glomeruli. On 10-year follow-up, a higher proportion of patients without enlarged glomeruli maintained CR compared to those with enlarged glomeruli (P = 0.004). Further, glomerular area and disease duration were significantly correlated (P = 0.04). Conclusions: Enlarged segmentally or minimally affected glomeruli at diagnosis of LN might predict a worse renal prognosis at 3 years after induction therapy. Mechanical glomerular injury might influence clinical outcomes. International Journal of Rheumatic Diseases

Original languageEnglish
Pages (from-to)768-775
Number of pages8
JournalInternational Journal of Rheumatic Diseases
Volume18
Issue number7
DOIs
Publication statusPublished - 2015 Sep 1

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Lupus Nephritis
Kidney
Rheumatic Diseases
Chronic Renal Insufficiency
Proteinuria

Keywords

  • Glomerulomegaly
  • Lupus nephritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Glomerulomegaly in lupus nephritis : A prognostic marker for renal outcomes. / Hanaoka, Hironari; Kuwana, Masataka; Takeuchi, Tsutomu.

In: International Journal of Rheumatic Diseases, Vol. 18, No. 7, 01.09.2015, p. 768-775.

Research output: Contribution to journalArticle

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