Glutathione isopropyl ester (YM737) inhibits the progression of x-ray-induced cataract in rats

Shizuko Kobayashi, Minako Kasuya, Keiko Shimizu, Yasuo Ishii, Makoto Takehana, Kazuo Sakai, Norio Suzuki, Motokazu Itoi

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16 Citations (Scopus)

Abstract

The effect of glutathione (GSH) isopropyl ester on the progression of X-ray-induced cataract was investigated in rats. Intraperitoneal administration of 20 mg/kg GSH isopropyl ester, three times weekly, 1 day after a single irradiation dose delayed the progression of X-ray-induced cataracts significantly. The amount of non-protein SH groups and the Na+/K+ ratio in the lenses of drug-treated rats were maintained at the normal levels even 27 weeks after irradiation. Posttreatment with the drug resulted in a significantly lower level of malondialdehyde in the irradiated lenses than in the non-treatted lenses. When 500 mg/kg GSH-isopropyl ester was administered by i.p. injection to normal rats, the GSH-ester was detected in plasma and aqueous humor after 15 min. In the lenses of the GSH-isopropyl ester-injected rats, the GSH level was 120% of that in the non-treated rats after 4 h, suggesting that GSH-isopropyl ester is transported from the aqueous humor to the lens and there converted to GSH after about 4 h. Our observations lead us to conclude that the delay of X-ray-induced lens opacity progression is due to maintenance of normal lenticular GSH levels achieved by post-irradiation administration of GSH-isopropyl ester. However, continuous administration of 100 mg/kg after irradiation had no effect on the progression of cataracts induced by X-rays.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalCurrent Eye Research
Volume12
Issue number2
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Kobayashi, S., Kasuya, M., Shimizu, K., Ishii, Y., Takehana, M., Sakai, K., Suzuki, N., & Itoi, M. (1993). Glutathione isopropyl ester (YM737) inhibits the progression of x-ray-induced cataract in rats. Current Eye Research, 12(2), 115-122. https://doi.org/10.3109/02713689308999479