Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting

Akihiro Ogura, Tsuyoshi Tahara, Satoshi Nozaki, Hirotaka Onoe, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing ∼10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1 h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.

Original languageEnglish
Pages (from-to)2251-2254
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number9
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

Keywords

  • A431 tumor
  • In vivo molecular imaging
  • Multivalency effects
  • N-Glycan
  • α(2,3)-Disialoglycan

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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