TY - JOUR
T1 - Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting
AU - Ogura, Akihiro
AU - Tahara, Tsuyoshi
AU - Nozaki, Satoshi
AU - Onoe, Hirotaka
AU - Kurbangalieva, Almira
AU - Watanabe, Yasuyoshi
AU - Tanaka, Katsunori
N1 - Funding Information:
All procedures involving experiment animals were approved by the Ethics Committee of RIKEN (MAH21-19-17). The experiments were performed in accordance with the institutional and national guidelines. This work was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science ( 22651081 , 23681047 , 25560410 , and 26560438 ), a Research Grant from the Mizutani Foundation for Glycoscience , MEXT Grants-in-Aid for Scientific Research on Innovative Areas (Nos. 26102743 and 15H05843 ), and an AstraZeneca R&D Grant. This work was also performed with the support of the Russian Government Program for Competitive Growth, granted to Kazan Federal University. The authors thank Glytech, Inc. for supplying various N-glycans.
Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing ∼10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1 h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.
AB - Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing ∼10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1 h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.
KW - A431 tumor
KW - In vivo molecular imaging
KW - Multivalency effects
KW - N-Glycan
KW - α(2,3)-Disialoglycan
UR - http://www.scopus.com/inward/record.url?scp=84962154863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962154863&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2016.03.046
DO - 10.1016/j.bmcl.2016.03.046
M3 - Article
C2 - 27020300
AN - SCOPUS:84962154863
SN - 0960-894X
VL - 26
SP - 2251
EP - 2254
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 9
ER -