Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting

Akihiro Ogura, Tsuyoshi Tahara, Satoshi Nozaki, Hirotaka Onoe, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing ∼10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1 h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.

Original languageEnglish
Pages (from-to)2251-2254
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number9
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

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Keywords

  • A431 tumor
  • In vivo molecular imaging
  • Multivalency effects
  • N-Glycan
  • α(2,3)-Disialoglycan

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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