Glycemic and metabolic features in gestational diabetes: Singleton versus twin pregnancies

Research output: Contribution to journalComment/debate

Abstract

A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. During the study period, women with GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. The glycemic and metabolic characteristics were compared between T-GDM and S-GDM, as follows: gestational week at the diagnosis of GDM, 75 g oral glucose tolerance test (OGTT) results, HbA1c, insulin secretion (i.e. insulinogenic index [IGI] and Insulin SecretionSensitivity Index-2 [ISSI-2]), and insulin requirement before delivery. The rate of one abnormal OGTT value in T-GDM was similar to that in S-GDM (60% vs. 71%). There were no significant differences in gestational week and levels of HbA1c at diagnosis, levels of IGI and ISSI-2 between T-GDM and S-GDM (median, 20 weeks vs. 17 weeks, 5.0% vs. 5.2%, 0.58 vs. 0.71, 1.7 vs. 1.8, respectively). The rate of insulin treatment and a median dosage of insulin needed before delivery was comparable between the two groups (T-GDM vs. S-GDM: 45% vs. 32% and 14 vs. 13 unit/day). Our data suggested that the severity of dysglycemia in T-GDM was similar to that in S-GDM during pregnancy.

Original languageEnglish
Pages (from-to)647-651
Number of pages5
JournalEndocrine journal
Volume66
Issue number7
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Twin Pregnancy
Gestational Diabetes
Insulin
Glucose Tolerance Test
Pregnancy
Blood Glucose Self-Monitoring

Keywords

  • Gestational diabetes mellitus
  • Severity of dysglycemia
  • Twin pregnancy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Glycemic and metabolic features in gestational diabetes : Singleton versus twin pregnancies. / Akiba, Yohei; Miyakoshi, Kei; Ikenoue, Satoru; Saisho, Yoshifumi; Kasuga, Yoshifumi; Ochiai, Daigo; Matsumoto, Tadashi; Tanaka, Mamoru.

In: Endocrine journal, Vol. 66, No. 7, 01.01.2019, p. 647-651.

Research output: Contribution to journalComment/debate

@article{78b5e62bb8e647b8af4ee10fad0468e8,
title = "Glycemic and metabolic features in gestational diabetes: Singleton versus twin pregnancies",
abstract = "A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. During the study period, women with GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. The glycemic and metabolic characteristics were compared between T-GDM and S-GDM, as follows: gestational week at the diagnosis of GDM, 75 g oral glucose tolerance test (OGTT) results, HbA1c, insulin secretion (i.e. insulinogenic index [IGI] and Insulin SecretionSensitivity Index-2 [ISSI-2]), and insulin requirement before delivery. The rate of one abnormal OGTT value in T-GDM was similar to that in S-GDM (60{\%} vs. 71{\%}). There were no significant differences in gestational week and levels of HbA1c at diagnosis, levels of IGI and ISSI-2 between T-GDM and S-GDM (median, 20 weeks vs. 17 weeks, 5.0{\%} vs. 5.2{\%}, 0.58 vs. 0.71, 1.7 vs. 1.8, respectively). The rate of insulin treatment and a median dosage of insulin needed before delivery was comparable between the two groups (T-GDM vs. S-GDM: 45{\%} vs. 32{\%} and 14 vs. 13 unit/day). Our data suggested that the severity of dysglycemia in T-GDM was similar to that in S-GDM during pregnancy.",
keywords = "Gestational diabetes mellitus, Severity of dysglycemia, Twin pregnancy",
author = "Yohei Akiba and Kei Miyakoshi and Satoru Ikenoue and Yoshifumi Saisho and Yoshifumi Kasuga and Daigo Ochiai and Tadashi Matsumoto and Mamoru Tanaka",
year = "2019",
month = "1",
day = "1",
doi = "10.1507/endocrj.EJ18-0575",
language = "English",
volume = "66",
pages = "647--651",
journal = "Endocrine Journal",
issn = "0918-8959",
publisher = "Japan Endocrine Society",
number = "7",

}

TY - JOUR

T1 - Glycemic and metabolic features in gestational diabetes

T2 - Singleton versus twin pregnancies

AU - Akiba, Yohei

AU - Miyakoshi, Kei

AU - Ikenoue, Satoru

AU - Saisho, Yoshifumi

AU - Kasuga, Yoshifumi

AU - Ochiai, Daigo

AU - Matsumoto, Tadashi

AU - Tanaka, Mamoru

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. During the study period, women with GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. The glycemic and metabolic characteristics were compared between T-GDM and S-GDM, as follows: gestational week at the diagnosis of GDM, 75 g oral glucose tolerance test (OGTT) results, HbA1c, insulin secretion (i.e. insulinogenic index [IGI] and Insulin SecretionSensitivity Index-2 [ISSI-2]), and insulin requirement before delivery. The rate of one abnormal OGTT value in T-GDM was similar to that in S-GDM (60% vs. 71%). There were no significant differences in gestational week and levels of HbA1c at diagnosis, levels of IGI and ISSI-2 between T-GDM and S-GDM (median, 20 weeks vs. 17 weeks, 5.0% vs. 5.2%, 0.58 vs. 0.71, 1.7 vs. 1.8, respectively). The rate of insulin treatment and a median dosage of insulin needed before delivery was comparable between the two groups (T-GDM vs. S-GDM: 45% vs. 32% and 14 vs. 13 unit/day). Our data suggested that the severity of dysglycemia in T-GDM was similar to that in S-GDM during pregnancy.

AB - A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. During the study period, women with GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. The glycemic and metabolic characteristics were compared between T-GDM and S-GDM, as follows: gestational week at the diagnosis of GDM, 75 g oral glucose tolerance test (OGTT) results, HbA1c, insulin secretion (i.e. insulinogenic index [IGI] and Insulin SecretionSensitivity Index-2 [ISSI-2]), and insulin requirement before delivery. The rate of one abnormal OGTT value in T-GDM was similar to that in S-GDM (60% vs. 71%). There were no significant differences in gestational week and levels of HbA1c at diagnosis, levels of IGI and ISSI-2 between T-GDM and S-GDM (median, 20 weeks vs. 17 weeks, 5.0% vs. 5.2%, 0.58 vs. 0.71, 1.7 vs. 1.8, respectively). The rate of insulin treatment and a median dosage of insulin needed before delivery was comparable between the two groups (T-GDM vs. S-GDM: 45% vs. 32% and 14 vs. 13 unit/day). Our data suggested that the severity of dysglycemia in T-GDM was similar to that in S-GDM during pregnancy.

KW - Gestational diabetes mellitus

KW - Severity of dysglycemia

KW - Twin pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85070010838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070010838&partnerID=8YFLogxK

U2 - 10.1507/endocrj.EJ18-0575

DO - 10.1507/endocrj.EJ18-0575

M3 - Comment/debate

C2 - 31019153

AN - SCOPUS:85070010838

VL - 66

SP - 647

EP - 651

JO - Endocrine Journal

JF - Endocrine Journal

SN - 0918-8959

IS - 7

ER -