Abstract
Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.
| Original language | English |
|---|---|
| Pages (from-to) | 3281-3283 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 13 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2003 Oct 16 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Glycidol-carbohydrate hybrids : A new family of DNA alkylating agents. / Toshima, Kazunobu; Okuno, Yukiko; Matsumura, Shuichi.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 19, 16.10.2003, p. 3281-3283.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glycidol-carbohydrate hybrids
T2 - A new family of DNA alkylating agents
AU - Toshima, Kazunobu
AU - Okuno, Yukiko
AU - Matsumura, Shuichi
PY - 2003/10/16
Y1 - 2003/10/16
N2 - Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.
AB - Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.
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UR - http://www.scopus.com/inward/citedby.url?scp=0042832962&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(03)00659-0
DO - 10.1016/S0960-894X(03)00659-0
M3 - Article
C2 - 12951109
AN - SCOPUS:0042832962
VL - 13
SP - 3281
EP - 3283
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 19
ER -