TY - JOUR
T1 - Glycidol-carbohydrate hybrids
T2 - A new family of DNA alkylating agents
AU - Toshima, Kazunobu
AU - Okuno, Yukiko
AU - Matsumura, Shuichi
N1 - Funding Information:
This research was partially supported by Grant-in-Aid for the 21st Century COE program ‘KEIO Life Conjugate Chemistry’ and for General Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan, and Takeda Science Foundation.
PY - 2003/10/16
Y1 - 2003/10/16
N2 - Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.
AB - Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.
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U2 - 10.1016/S0960-894X(03)00659-0
DO - 10.1016/S0960-894X(03)00659-0
M3 - Article
C2 - 12951109
AN - SCOPUS:0042832962
VL - 13
SP - 3281
EP - 3283
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 19
ER -