Abstract
Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.
| Original language | English |
|---|---|
| Pages (from-to) | 3281-3283 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 13 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2003 Oct 16 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Toshima, K., Okuno, Y., & Matsumura, S. (2003). Glycidol-carbohydrate hybrids: A new family of DNA alkylating agents. Bioorganic and Medicinal Chemistry Letters, 13(19), 3281-3283. https://doi.org/10.1016/S0960-894X(03)00659-0