Glycidol-carbohydrate hybrids: A new family of DNA alkylating agents

Kazunobu Toshima; Yukiko Okuno; Shuichi Matsumura

doi:10.1016/S0960-894X(03)00659-0

Glycidol-carbohydrate hybrids: A new family of DNA alkylating agents

Kazunobu Toshima, Yukiko Okuno, Shuichi Matsumura

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.

Original language	English
Pages (from-to)	3281-3283
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	19
DOIs	https://doi.org/10.1016/S0960-894X(03)00659-0
Publication status	Published - 2003 Oct 16

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(03)00659-0

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title = "Glycidol-carbohydrate hybrids: A new family of DNA alkylating agents",

abstract = "Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.",

author = "Kazunobu Toshima and Yukiko Okuno and Shuichi Matsumura",

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AB - Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.

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