Glycidol-carbohydrate hybrids: A new family of DNA alkylating agents

Kazunobu Toshima, Yukiko Okuno, Shuichi Matsumura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.

Original languageEnglish
Pages (from-to)3281-3283
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number19
DOIs
Publication statusPublished - 2003 Oct 16

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glycidol
Alkylating Agents
Carbohydrates
DNA
Guanine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Glycidol-carbohydrate hybrids : A new family of DNA alkylating agents. / Toshima, Kazunobu; Okuno, Yukiko; Matsumura, Shuichi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 19, 16.10.2003, p. 3281-3283.

Research output: Contribution to journalArticle

Toshima, Kazunobu ; Okuno, Yukiko ; Matsumura, Shuichi. / Glycidol-carbohydrate hybrids : A new family of DNA alkylating agents. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 19. pp. 3281-3283.
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